ANALYST VIEWS: IS WILLIAM HILL IN LINE FOR A BIG WIN? Tags: NULL whatsapp More From Our Partners Native American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgKiller drone ‘hunted down a human target’ without being told tonypost.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.org‘Neighbor from hell’ faces new charges after scaring off home buyersnypost.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comI blew off Adam Sandler 22 years ago — and it’s my biggest regretnypost.com IVOR JONES | NUMIS The share price has continued to be weak and William Hill has fallen to a level where we believe it is right to pick up shares for the medium-term. We are changing our recommendation to ‘add’ from ‘hold’.GEETANJALI SHARMA | EXECUTION NOBLE William Hill’s performance is impressive as its 26 per cent group net revenue increase compares with eight per cent at Ladbrokes. Management is being cautious on the expectations given the larger consumer concerns.NIGEL PARSON | EVOLUTION SECURITIES William Hill’s results show no major surprises, with flat Ebitda driven by online growth and a strong World Cup, offset by horseracing results and higher marketing costs. The retail cash generation supports a solid dividend yield. KCS-content Ad Unmute by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeMoneyPailShe Was A Star, Now She Works In ScottsdaleMoneyPailUndoNoteabley25 Funny Notes Written By StrangersNoteableyUndoZen HeraldThe Truth About Why ’40s Actor John Wayne Didn’t Serve In WWII Has Come To LightZen HeraldUndoBetterBe20 Stunning Female AthletesBetterBeUndoCrowdy FanShe Didn’t Know Why Everyone Was Staring At Her Hilarious T-ShirtCrowdy FanUndoautooverload.comDeclassified Vietnam War Photos The Public Wasn’t Meant To Seeautooverload.comUndoAtlantic MirrorA Kilimanjaro Discovery Has Proved This About The BibleAtlantic MirrorUndoTotal PastThe Ingenious Reason There Are No Mosquitoes At Disney WorldTotal PastUndoElite HeraldKate Middleton Dropped An Unexpected Baby BombshellElite HeraldUndo Share whatsapp Show Comments ▼ Thursday 26 August 2010 8:23 pm
Tags: NULL whatsapp Private equity firm Blackstone is considering a takeover bid of Southern Cross. The British care home operator said last week it was in early-stage talks with other potential buyers after private equity firm Towerbrook Capital announced it was no longer interested in making an offer. Blackstone owned Southern Cross before listing it in 2006 and is reportedly now keen on launching a takeover of the listed operating company and its property company, with a view to combining them. Blackstone and Southern Cross could not be reached for comment yesterday. whatsapp Blackstone eyes Southern Cross More From Our Partners Police Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgInside Ashton Kutcher and Mila Kunis’ not-so-average farmhouse estatenypost.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgSupermodel Anne Vyalitsyna claims income drop, pushes for child supportnypost.com Show Comments ▼ KCS-content Share Sunday 28 November 2010 10:02 pm
Our 6 ‘Best Buys Now’ Shares Simply click below to discover how you can take advantage of this. I’m sure you’ll agree that’s quite the statement from Motley Fool Co-Founder Tom Gardner.But since our US analyst team first recommended shares in this unique tech stock back in 2016, the value has soared.What’s more, we firmly believe there’s still plenty of upside in its future. In fact, even throughout the current coronavirus crisis, its performance has been beating Wall St expectations.And right now, we’re giving you a chance to discover exactly what has got our analysts all fired up about this niche industry phenomenon, in our FREE special report, A Top US Share From The Motley Fool. A lack of savings when you’re young doesn’t really bother most people. But as they start to raise a family, look for career progression, and potentially buy a house, savings become very important. For some, it’s impossible to build up a pool of money to be invested because of large expenses or low income.Yet the recent stock market crash has seen large, reputable companies have billions wiped off their valuations. This makes some stocks look very attractive to buy into. Even with no savings and only a small amount of initial investment, it could be the start you need to get involved in the markets. This can hopefully build your savings into the longer term.5G is here – and shares of this ‘sleeping giant’ could be a great way for you to potentially profit!According to one leading industry firm, the 5G boom could create a global industry worth US$12.3 TRILLION out of thin air…And if you click here we’ll show you something that could be key to unlocking 5G’s full potential…How much do I need to invest?Unlike buying a property or a corporate bond, there’s no minimum amount to invest in the stock market. The share price of a company may be 100p. So you can buy any denomination of the share. If you buy 500 shares it’ll cost you £500. This flexible aspect of stock investing allows you to start off with a small amount of money.It also allows you to be diversified in your investing approach. If I had a few hundred pounds to invest with no savings, I’d split it up into buying several different stocks. For example, I’d buy a stock which pays me a dividend, one which I think could be high growth in the future, and one which is very defensive. One good growth firm is Boohoo Group.This strategy of diversification remains the same, whether I’m investing £100,000 or £100.Why buy now?No one has managed to escape the coronavirus’s impact on the world. The stock market has taken a hit, as most of the companies within it has seen a fall in revenues and profit. Most consumers are simply not spending money on anything except the necessities, and certainly not taking advantage of the travel or entertainment sector. At some point, the virus likely will recede to a level whereby these sectors can reopen and resume business. In these cases, I think we’ll see a turnaround in business, although maybe not until next year. As a long-term investor, you can grow your savings better when it compounds over time. So investing now when stocks trade at historical lows can allow you to buy and hold them for many years to come.No savings = no problemEveryone has to start somewhere when looking to build an investment portfolio. Just because you don’t have savings at present doesn’t mean it has to stay like that. Taking advantage of the stock market crash is a good way to start. Given the small minimum amount to invest, you can feel comfortable with whatever sum you decide on. Renowned stock-picker Mark Rogers and his analyst team at The Motley Fool UK have named 6 shares that they believe UK investors should consider buying NOW.So if you’re looking for more stock ideas to try and best position your portfolio today, then it might be a good day for you. Because we’re offering a full 33% off your first year of membership to our flagship share-tipping service, backed by our ‘no quibbles’ 30-day subscription fee refund guarantee. I would like to receive emails from you about product information and offers from The Fool and its business partners. Each of these emails will provide a link to unsubscribe from future emails. More information about how The Fool collects, stores, and handles personal data is available in its Privacy Statement. Click here to claim your copy now — and we’ll tell you the name of this Top US Share… free of charge! Enter Your Email Address No savings at 40? Here’s why the stock market crash can be the ideal time to start investing Jonathan Smith does not own shares in any firm mentioned. The Motley Fool UK has recommended boohoo group. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors. Jonathan Smith | Friday, 22nd May, 2020 “This Stock Could Be Like Buying Amazon in 1997” Image source: Getty Images See all posts by Jonathan Smith
Image source: Getty Images. Renowned stock-picker Mark Rogers and his analyst team at The Motley Fool UK have named 6 shares that they believe UK investors should consider buying NOW.So if you’re looking for more stock ideas to try and best position your portfolio today, then it might be a good day for you. Because we’re offering a full 33% off your first year of membership to our flagship share-tipping service, backed by our ‘no quibbles’ 30-day subscription fee refund guarantee. Simply click below to discover how you can take advantage of this. Here’s how I think BP gets a higher valuation “This Stock Could Be Like Buying Amazon in 1997” Our 6 ‘Best Buys Now’ Shares Enter Your Email Address I would like to receive emails from you about product information and offers from The Fool and its business partners. Each of these emails will provide a link to unsubscribe from future emails. More information about how The Fool collects, stores, and handles personal data is available in its Privacy Statement. Click here to claim your copy now — and we’ll tell you the name of this Top US Share… free of charge! I’m sure you’ll agree that’s quite the statement from Motley Fool Co-Founder Tom Gardner.But since our US analyst team first recommended shares in this unique tech stock back in 2016, the value has soared.What’s more, we firmly believe there’s still plenty of upside in its future. In fact, even throughout the current coronavirus crisis, its performance has been beating Wall St expectations.And right now, we’re giving you a chance to discover exactly what has got our analysts all fired up about this niche industry phenomenon, in our FREE special report, A Top US Share From The Motley Fool. See all posts by Jay Yao Jay Yao | Thursday, 29th October, 2020 | More on: BP Jay Yao has no position in any of the shares mentioned. The Motley Fool UK owns shares of and has recommended Tesla. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors. Many stocks associated with renewable energy and electric vehicles such as Tesla have done really well. As a result, they are trading at fairly high multiples. BP (LSE: BP) recently pivoted more into green energy by stating a commitment to invest substantially more in the sector over the next 10 years. One might think the oil giant would benefit from the pivot with a potential bounce. Alas, however, the oil giant’s stock hasn’t rallied, despite the green commitment, and its stock is near yearly lows. 5G is here – and shares of this ‘sleeping giant’ could be a great way for you to potentially profit!According to one leading industry firm, the 5G boom could create a global industry worth US$12.3 TRILLION out of thin air…And if you click here we’ll show you something that could be key to unlocking 5G’s full potential…In terms of the near-term stock price, why has the market given the ‘cold shoulder’ to BP’s green strategy?Here’s why I think the market hasn’t given BP the same credit it has to green stocks, and why I think there is nevertheless an opportunity. It takes time for the market to buy into BP’s renewable energy pivotWhile BP has stated a commitment to change its investment strategy, I think it takes time to change investor perception. When most people hear ‘BP’, they still think ‘oil and gas’. So, they group BP stock in with other oil and gas companies that don’t necessarily have the same commitment to green energy. Speaking of oil and gas, oil prices haven’t done well. The price of the commodity is still weak due to the pandemic and sluggish global macroeconomic factors. China’s economy has turned back to growth. But the current partial lockdowns in Europe have not helped with demand in the West. I believe the fear that ‘it could get worse before it gets better’ during winter in terms of Covid-19 has hurt sentiment for oil prices too. Nevertheless, I think the market will eventually buy more into BP’s green push as the company makes more progress in the field. I also think management continuing to mention the green pivot in investor presentations will help.As it makes more progress in the field, I think the company’s valuation could benefit as a result. The potential green tech I think could boost sentimentIn addition to changing perception via investor presentations, I think BP making progress in green tech R&D and market share could also eventually benefit the company’s valuation. There are many green techs, and BP has committed to investing substantially in solar, wind, bioenergy, hydrogen, and carbon capture. But I think most important is what the company does as it relates to fusion. Given its safe and transformative potential, fusion will be a huge market that will revolutionise electricity generation when it arrives, in my view. According to recent studies made public by MIT-associated scientists, the technology could be commercial ready as early as the 2030s. There’s a lack of fusion-focused investments in the public market at present. I think it’s likely that investors will bid up the valuation of any integrated oil company that invests heavily in fusion and emphasises the technology to investors.
Boschini: ‘None of the talk matters because Jamie Dixon is staying’ Previous articleSMS Message TCU vs. ISU #15Next articleFamilies and alumni go purple Garrett Podell RELATED ARTICLESMORE FROM AUTHOR Linkedin ReddIt Garrett is a Journalism and Sports Broadcasting double major. He is the Managing Editor for TCU360, and his passions are God, family, friends, sports, and great food. printTCU opened up its fifth season in the Big 12 Conference with a 41-20 victory over the Iowa State Cyclones on Saturday morning.The Horned Frogs are now 4-1 versus Iowa State in Big 12 play and 7-1 overall in the series history. The Frogs are now 32-11 in regular-season games.Head football coach Gary Patterson said he wasn’t pleased about the injuries to wide receiver KaVontae Turpin, defensive end Josh Carraway and cornerback Jeff Gladney.“Too many people got banged up, and there was not enough emotion,” Patterson said. “Here’s what happens when you don’t have emotion: People get hurt, and when you’re the nail and not the hammer, you get hurt, simple as that.”Patterson did appreciate the freshman corner’s performance before his injury, “Gladney did a nice job until he got hurt, and they [the defense] seemed a bit more settled down than a week ago.”Wide receiver Deanté Gray got the start at cornerback in place of Ranthony Texada for his second defensive start of his Horned Frog career, both of them against Iowa State.“He [Deanté Gray] played a little bit, but not in the second half,” Patterson said. “He’ll probably go back to offense next week.”Defensive end Mat Boesen saw his first game action for the Frogs in Saturday’s contest, after dealing with a shoulder injury during the first two weeks of the season. He finished the game with 1.5 sacks and a pass break-up. Boseon transferred to TCU from Boise State.“He [Boeson] did alright, it was good to have another guy to rotate in there,” Patterson said. “We’re probably going to have to have six or seven defensive ends play this season.”The first-quarter sack by Boesen extended TCU’s school record streak to 33 games with at least one sack. It is the second-longest active streak in the nation, behind only Ohio State with 37. Defensive end Aaron Curry had a sack to give him a team-best 2.5 on the season, and defensive end Tipa Galeai had his first sack of the season and second of his career.Offensively, TCU had a solid outing, totaling 481 yards of total offense and 229 yards on the ground. The Frogs are now 81-5 under Patterson when rushing for at least 200 yards. After a field goal on their first possession, the Horned Frogs notched the first touchdown of the game with five-and-a-half minutes left in the first quarter when running back Kyle Hicks ran for an effortless 64-yard touchdown run. Hicks’ 64-yard touchdown run was the longest carry of his career. This gives him five rushing touchdowns in just three games this season.The 64-yard scoring run by Hicks was the longest carry by a Horned Frog since Trevone Boykin had a 69-yard touchdown rush at Kansas State last season.Hicks deflected the credit on his scoring run.“I was just glad to have [Joseph]Noteboom running alongside of me,” Hicks said. “I was just trying to cut off is block and make a good read.”Patterson said Hicks has been a bright spot on the team.“It’s why Kyle Hicks is one of four captains,” Patterson said. “He’s everything you want on and off the field.”All three running backs who played against the Cyclones ran for a touchdown. Michigan transfer Derrick Green had one-yard touchdown run in the second quarter and Trevorris Johnson’s two-yard third-quarter scoring run was his first of the season and fifth of his career.Hicks had his first career 100-yard rushing game with a team-best 117 yards on 12 carries.TCU quarterback Kenny Hill’s one-yard scoring run in the second quarter was his team-high sixth rushing touchdown of the season. He has run for a score in all three games this season.To start the second half, TCU’s balanced attack marched all the way to Iowa State 25-yard line after converting a fourth-and-four. On the very next play, Kenny Hill threw a strike to running back Kyle Hicks for 21-yard touchdown, increasing the Horned Frog lead to 31-7.“That catch, he’s probably got some of the best hands and he showed them,” TCU quarterback Kenny Hill said. Facebook Men’s basketball scores season-low in NIT semifinals loss to Texas Garrett Podellhttps://www.tcu360.com/author/garrett-podell/ TCU rowing program strengthens after facing COVID-19 setbacks Garrett Podellhttps://www.tcu360.com/author/garrett-podell/ TCU running back Trevor’s Johnson sprints into the end zone for a touchdownPhoto Courtesy of Sam Bruton Another series win lands TCU Baseball in the top 5, earns Sikes conference award Garrett Podellhttps://www.tcu360.com/author/garrett-podell/ + posts Linkedin TAGStext only Twitter Facebook ReddIt TCU’s next game is Friday in Dallas against SMU at 7 p.m. Garrett Podellhttps://www.tcu360.com/author/garrett-podell/ Twitter Listen: The Podell and Pickell Show with L.J. Collier Garrett Podell Boschini talks: construction, parking, tuition, enrollment, DEI, a student trustee TCU baseball finds their biggest fan just by saying hello
News IraqMiddle East – North Africa December 28, 2020 Find out more Organisation RSF_en December 16, 2020 Find out more Follow the news on Iraq February 15, 2021 Find out more Iraq : Wave of arrests of journalists covering protests in Iraqi Kurdistan Receive email alerts News News Three jailed reporters charged with “undermining national security” Reporters Without Borders today called for the release of Ahmed Mahmud Hassan, of satellite al-Sumariya television, who has been held since 30 March by the Iraqi authorities, who have not given any reason for his arrest.Mahmud Hassan was picked up in Mahmudiya, 30 kms south of Baghdad, while he was covering clashes between Iraqi forces and rebel insurgents. He is thought to be detained in a military base. A score of journalists have been arrested across Iraq since the start of 2008.“Arbitrary arrest has become commonplace in Iraq. The Iraqi authorities must stop this growing obstruction to the work of the media,” the worldwide press freedom organisation said.“There is no reason for the continued detention of Ahmed Mahmud Hassan who should be quickly released”.Elsewhere, insurgents linked to the Mahdi Army set fire to the home of Bashir Thaaban, of Iraqi public radio in Kut, 180 kms south of Baghdad. The studios of al-Irakiya televisioin, which is also part of the public Iraqi Media Network, were ransacked and torched in the southern city of Basra, 550 kms from Baghdad. A total of 210 journalists have been killed since the start of the war in Iraq in March 2003. Dozens of journalists have been kidnapped, 15 of whom are still missing. News RSF’s 2020 Round-up: 50 journalists killed, two-thirds in countries “at peace” April 1, 2008 – Updated on January 20, 2016 Call for release of journalist on al-Sumariya TV IraqMiddle East – North Africa to go further Help by sharing this information
ColumnsUnderstanding The Regulatory Regime For Clinical Trials In India Nidhisha Garg21 Aug 2020 3:30 AMShare This – xThe process of developing a new drug, which has preventive or curative effects on ailments, is known as a ‘clinical trial’. However, like all other human activities, there exits laws for regulating this process. This article examines the procedure for developing a vaccine as mandated by law in India and globally and the deficiencies given the need of the hour. History of the…Your free access to Live Law has expiredTo read the article, get a premium account.Your Subscription Supports Independent JournalismSubscription starts from ₹ 599+GST (For 6 Months)View PlansPremium account gives you:Unlimited access to Live Law Archives, Weekly/Monthly Digest, Exclusive Notifications, Comments.Reading experience of Ad Free Version, Petition Copies, Judgement/Order Copies.Subscribe NowAlready a subscriber?LoginThe process of developing a new drug, which has preventive or curative effects on ailments, is known as a ‘clinical trial’. However, like all other human activities, there exits laws for regulating this process. This article examines the procedure for developing a vaccine as mandated by law in India and globally and the deficiencies given the need of the hour. History of the Legal Framework Concerning Clinical Trials in India The pharmaceutical industry is largely governed by the Drugs and Cosmetics Act, 1940 as the umbrella legislation along with the associated Drugs and Cosmetics Rules, 1945. Part XA and Schedule Y of these rules was the first systematic regulatory framework for clinical trials in independent India. However the report of the Ranjit Roy Choudhary Committee in the year 2013 highlighted several shortcomings in the incumbent framework, which was buttressed by the opinion of the Supreme Court in the case of Swasthya Adhikar Manch, Indore v. Ministry of Health and Family Welfare. Therefore significant amendments were introduced by the way of the Drugs and Cosmetics (Third Amendment) Rules, 2013. It was only in Kalpana Mehta v. Union of India, that the Supreme Court came to note that the blatant violation of human rights that occurs when minor girls and other members from vulnerable communities are forced to become subjects for clinical trials without even apprising them of the adverse effects it may have on their health. Therefore, the Apex Court directed the Central Government to bring about an overhaul in the regulatory regime with roper checks and balances in place to ensure fair conduct of clinical trials. When the government failed to respond within the given time, it gave an ultimatum of two weeks’ time for formulation of the new rules, following which draft rules for a new framework were submitted for public consultation. Finally, in March 2019, the incumbent New Drugs and Clinical Trial Rules, 2019 (the Rules) were adopted. Clinical Trials: The Application Before initiating clinical trial, an applicant is first required to submit an application to the Central Licensing Authority (CLA) of the Central Drugs Standards Control Organisation (CDSCO). The Drugs Controller General of India (DCGI) usually acts as the CLA. However, before such application can be preferred, it is important that the applicant collect data of pre-clinical studies. These are studies conducted on animals resembling immune systems similar to humans. These studies provide the preliminary data regarding the prospects of a vaccine. Alternatively, the applicant can also choose to have pre-submission meetings and discussion with the CLA to gauge the prospects of approval. The subject-expert committees scrutinize the application in this regard. The application when submitted along with results of pre-clinical studies, must be either accepted or rejected within 30 days, if the drug is sought to be manufactured in India and within 90 days, if the drug is sought to be manufactured outside India. In case, the CLA gives no response within the prescribed time limits, it is deemed that the approval has been granted. There are only two circumstances under which there is no requirement of submitting an application. These are: When the drug is sought to be manufactured solely for academic purposes, andWhen the drug has already received approval for marketing in any of the countries listed in the Schedule. Parallelly, the applicant is also required to secure approval of the Ethics Committee (EC). This is a committee constituted by the applicant himself however, there are statutory guidelines for its constitution, for example, it must consist a minimum of 7 members, half of them must be independent members having no relation to the applicant, it must adequate representation from medical experts, pharmacologists, general laymen of society etc. A clinical trial consists of three primary constituents, the sponsor, the investigator and the subjects. . The sponsor is vested with funding the trial and arranging for logistical requirements, such as a safe venue for the trial, equipment, laboratories, tools etc. A sponsor may be a natural person or a medical institution. The investigator is a qualified pharmacologist who carries out the trial and the subjects are the humans on whom the trial is conducted. Clinical Trials: The Procedure After getting the approval, the applicant may begin the clinical trial, which consist of four phases. The first phase consist of clinical pharmacological study in which the drug is tested for any adverse effects on human. For this, not more than 2-3 healthy humans are selected and they are administered the drug to ensure that the drug does not cause any severe adverse effect on humans. Post this, phase two of the trial, also known as the exploratory phase commences. Under this phase, a homogenous group of 10-12 people, that is, people of the same age group, having similar medical histories etc. are selected and the therapeutic effects of the drug on this group are recorded. If positive results are obtained during the second phase, the researcher may proceed with the third and the most important phase. The third and the most important phase called the confirmatory phase involves testing the drug on thousands of people, heterogeneous in their age groups, genders, medical histories and physiological factors. Once the CLA is satisfied of the success of phase three, the approval for large scale manufacturing and market distribution of the drug is given. There also exists a fourth phase, called the ‘Post-Approval Studies’. It involves further research on more intricate aspects of the drug, after the approval for its development on a large scale has been given. Principles Governing Clinical Trials The subjects which are chosen for the trial must be duly informed of the entire treatment that is to be meted out to them along with the possible side effects if any. This is to guarantee informed consent of those on whom the new drug shall be tried. The consent has to be voluntary and in writing. The subject must be informed that he or she has the right to withdraw from the procedure at any time. Relatives of the subject also possess the Right to Information and ask the investigator about any doubts that they might have. If the subject is a minor, due consent must be obtained from the legal guardian. Along with this, the investigator must commit to keep medical records and other information pertaining to the subjects completely confidential. Prior to the commencement of the trial, the sponsor and the investigator are required to enter into a Pre-Trial Agreement, which has clauses providing for the responsibilities of each of them, fees to be paid by the sponsor, the standard of care to be ensure by the investigator etc. It also consists of a detailed Standard Operating Procedure (SoP) which lays down the step-by-step procedure to be followed by the investigator. The investigator is obligated with providing detailed records of results and progress made. Each subject must have a separate Case Report Form (CRF). The same have to be submitted by the investigator to the authorities. The sponsor may appoint a monitor in his discretion, who shall oversee that the investigator is carrying out the trial as per the agreement and the SoP. Throughout the process of the trial, the investigators are required to adhere to three cardinal principles of clinical trials, as provided by the Helsinki Declaration, 1964. They are: JusticeRespect for PersonsBeneficence International Standards for Clinical Trials When it comes to international legal standards for clinical trials, the WHO Guidelines on Good Clinical Practices for Trials on Pharmaceutical Products, 1995 form the model law. Regulatory frameworks of most prominent jurisdictions are based on the WHO guidelines. However, some of the salutary provisions in these frameworks which may also be adopted by India have been discussed below. Clinical Trial Networks: The U.S. framework has provisions for collaboration with other countries in case there exists a scenario where more than one countries are simultaneously working on developing a drug. It allows investigators of U.S.A to join other clusters across the globe conducting similar trials. The Indian framework lacks such a provisions. However, such a provision is of extreme importance, especially in current times when the entire world is trying to develop a vaccine for a single virus. Tiered structure: The EU divides its clinical trials into three categories- (1) Clinical Trials, (2) Low-Interventional Studies and (3) Non-interventional studies. While the EU Regulation No. 536/2014 is not applicable to non-interventional studies, it applies to low-interventional studies only in a limited sense. Low-interventional studies involve use of non-authorized is their use is evidence-based and supported by the published scientific evidence. These trials should not pose more than a minimal additional safety risk or burden to participants compared to normal clinical practice. While the Indian framework for clinical trials is appreciable on many counts, there is still some scope of improvements is some aspects. For example, India is yet to be member of the Pharmaceutical Inspection Co-operation Scheme despite repeated requests from industry stakeholders to the Centre in this regard. Similarly, there is a need for explanatory notes by DCGI, training institutes for ECs and investigators etc. The requirements for additional approval by the Genetic Engineering Approval Committee (GEAC) in certain cases also makes the process more time-consuming and increases the regulatory hassles. Despite these, the silver lining is that ICMR is constantly working to better the Indian framework. For instance, talks are under way to develop specialized clinical trial centers affiliated with ICMR, which will overhaul the current lengthy procedure. Similarly, a relaxation in some norms has been given in light of efforts to develop a vaccine for COVID-19. With this, one can only hope that the otherwise stringent regulatory framework for clinical trials in India does not pose as a hindrance for development of a COVID-19 vaccine.Views are personal only. Next Story
Photo: Matt Rea Load remaining images Phish made their return to Hampton, VA’s infamous Hampton Coliseum, a venue that holds a special place in both the band and fans’ hearts for so many reasons. Following a well-received two-night run to open their fall tour in Albany, Phish delivered an impressive opening night in Hampton, perfectly placing rarities, and laying down a sizable amount of deep type II territory, which ignited the all-GA venue.With the Mothership crowd roaring before the band took the stage, Phish came out and opened the first set with “Strawberry Letter 23”, played for only the second time ever, as it was only debuted on the second night of Phish’s 13-night Bakers Dozen run. Phish’s vocals sound particularly refined and in tune this tour, and the four-piece did a fantastic job harmonizing behind Trey Anastasio’s lead vocals on the beloved Shuggie Otis cover. Next up was “Blaze On”, which led way to aggressive type II territory out of the gates. After bringing the chorus back, the band continued to push further out, adding a touch of an extended outro.A massive bust-out followed, as Phish dove into “Mock Song”, played for the first time since 2015’s Magnaball, and only the third time ever. The Mike Gordon-led tune off of 2002’s Round Room includes a difficult lyrical punch, so Gordon had an assist with lyrics written out on pieces of cardstock. The band sounded confident and driven with their ballsy song selection, with Gordon shining bright, no pun intended. Lighting designer extraordinaire, Chris Kuroda, turned Hampton into a fluorescent ocean of love the entire evening, as his rig dangled above the band.“Divided Sky” followed up “Mock Song”, as the band took a brief pause before slowly drifting into the familiar theme of “Roggae”. With Jon Fishman and Gordon locking in the rhythm section, Anastasio took off, as Page McConnell followed his every move with extreme precision. The Hampton Coliseum exploded with applause as the band reeled “Roggae” back in, before taking a brief pause to catch their breaths.Picking up the pace, Phish delivered a high-energy, yet standard “Sparkle”, as Kuroda illuminated the rowdy crowd with a solid-red pattern. Before the crowd completely laughed, and laughed, and fell apart, Phish quickly collected themselves, allowing Fishman enough time to lay down his signature “Undermind” beat. Towards the end of “Undermind”, Anastasio took the stage front and center, inviting the crowd to clap along with him. Gordon and McConnell quieted things down for Fishman, as the octopus-like drummer rolled through his toms and cymbals.“Meat” was up next, as Gordon led his bandmates, dropping some thunderous “Mike-bombs” along the way. As Trey has done every show this tour, he slowly approached Mike, as they directly faced each other, with shit-eating grins from ear to ear. Hampton’s a place where Phish finds their comfort zone without hesitation, and the band’s interplay with each other tonight exemplified this notion. “Rift” followed, with McConnell whipping up a whirlwind of a solo on the grand piano, before Trey and Mike delivered the signature finale, tapping themselves on the throat as the last notes of “Rift” rung out. Phish closed out the first set with a cover of James Gang’s “Walk Away”, a tune that did not get any attention over Phish’s recent summer tour.Phish opened the second set with “Carini”, immediately dropping into some dark and evil Phish, with Anastasio and Fishman howling, “Carini had a lumpy head.” With an apparent mid-show outfit change, Gordon hammered away on his Modulus bass, before Anastasio and McConnell quickly found their sweet spot together. Trey led the way into a psychedelic pocket, before the band slowly trickled away, bouncing harmoniously into “Sand”. Anastasio and Gordon threw in a “Strawberry Letter 23” tease as the band set the gearshift for takeoff. Following some piping hot interplay between Anastasio and McConnell, the band took a blissful stride before seguing into “Golden Age”.“Golden Age” took a wild ride, with multiple segments delicately woven together. Midway through the jam, Fishman took charge and slowed things down, before McConnell quickly started playing with intergalactic spacey-noises, inviting Anastasio to set the bar for the remainder of the jam. McConnell tossed in a heavy dose of 2014’s Halloween teases, before the band fizzled out of “Golden Age” with a spooky, dark vibe. A tight-knit “Twist” continued in the second set’s theme of heavy improvisation, before the quartet took a breather to collect themselves.“Mountains In The Mist” followed, as Trey delivered his lead vocal portion of the song with punctuality. McConnell led his bandmates into “Meatstick”, with Gordon holding it down as he glimmered in his sparkly-silver shirt. Phish brought their second set to a close with “Split Open and Melt”, taking the tune into some dark and gloomy space. Anastasio let it all hang out during the “Melt”, firing off an ever-evolving solo, until the band connected to bring the peaking jam to a close. Coming back out for their encore, Phish took no time to dive into “The Lizards”, played for the first time ever at Hampton Coliseum. If the first night of Phish’s Hampton run is any indicator of what the next two nights will bring, fans better buckle up for a wild ride!Phish returns to the Hampton Coliseum tonight for their second show of the highly anticipated three-night run. The band follows their Hampton run up with a two-night stand at Nashville, TN’s fan-favorite venue, Ascend Amphitheatre, a three-night stand at Allstate Arena in Rosemont, IL, and wrap up their fall tour with a four-night Halloween run at the MGM Grand Garden Arena.Setlist: Phish | Hampton Coliseum | Hampton, VA | 10/19/2018Set One: Strawberry Letter 23, Blaze On> Mock Song, Divided Sky, Roggae, Sparkle, Undermind, Meat, Rift> Walk AwaySet Two: Carini> Sand> Golden Age, Twist, Mountains In The Mist, Meatstick, Split Open and MeltEncore: The LizardsPhish | Hampton Coliseum | Hampton, VA | 10/19/2018 | Photos: Matt Rea Photo: Matt Rea
Later, Marshall commented on the lackluster state of many other Broadway shows—acknowledging he was getting himself into hot water—saying, “The majority of shows feel sanitized, lack artistry and storytelling.” Cumming agreed, adding, “People expect a big production, and in that, something is lost. These are different times. But this show, it’s about the actors.” Taking his cue, Rooney mused, “So, you’re not 28 anymore, and you’re applying rouge to your nipples and donning suspenders—at middle age—what is that like?” Cumming, without missing a beat, replied, “You know, I’m fitter now than I was when I first did the show 16 years ago. Although, I do have to go for more naps now.” When asked if they’ve begun rehearsing at the legendary Studio 54 yet, Cumming replied, “We’re in the theater in a couple of weeks.” Williams then put her fingers in her ears and sang, “La-la-la-la-la…” Of her decision to take the role, Williams said, “Some people call it bravery, but really, I call it my inability to see a decision through to the end when I say ‘yes.’” “One day, I grabbed this old bloke with a mustache to bring him on stage to dance and said, ‘Come along, Granddad,’ and the whole audience stated cheering and whooping. I thought, ‘Wow, aren’t Americans so nice to their elderly!’ When I asked, ‘What’s your name?’ He said, ‘Cronkite.’ It was Walter Cronkite. A year later I saw him at a party, and when he started coming toward me, I thought I was about to get bitch-slapped. Instead, he said, ‘May I please have this dance?’” View Comments Alan Cumming Rooney forgot his next question, so Cumming offered, “I have a question for you, where did you get your shoes?” Show Closed This production ended its run on March 29, 2015 Star Files Related Shows Cabaret Tony winner Alan Cumming, Academy Award nominee Michelle Williams, and co-director and choreographer Rob Marshall spoke to an audience on the edge of their plush red seats at The New York Times headquarters on February 24 about bringing Cabaret back to Broadway this spring. To hear Williams tell it, she isn’t exactly kicking up her heels at the prospect of dancing in front of throngs of devoted Broadway fans in the return of the musical. “They were generous enough to start me a few months before everyone else. I’ve been taking classes in a studio in Brooklyn and I’m basically being a kid there. I feel like a baby,” she said. “I get to rehearsal, and I’m like, ‘What do I do?’” See Michelle Williams and Alan Cumming in Cabaret beginning March 21 at Studio 54. After being prompted by discussion moderator and Times staffer David Rooney, Cumming shared the story of how he pulled a very special—and very old—guest onstage with him during his 1998 stint in the show. Cabaret has seen multiple incarnations since its initial 1966 inception, most recently making its biggest splash at Studio 54 in the 1998 revival. The story, which takes place during the rise of Nazi Germany in the 1930s, reins in the audience with promises of sexy, voyeuristic glimpses into an underworld—only to suddenly stop them in their tracks when they see that the world they’re in isn’t all it’s cracked up to be—in fact, it’s quite horrific. Their only guide through that journey is by one Emcee, played by Cumming like nobody else can. The actor noted that the themes of the story are still relevant, especially with the laws currently being passed in Russia. “The way they’re persecuting gays is similar to what went on in Nazi Germany. Sadly, that kind of bigotry doesn’t go away.” Turning to the audience, he said, “Did you know that in Arizona, it’s legal for a business not to serve someone if they’re gay?” Michelle Williams
Songwriters like Townes Van Zandt, Chris Smither, and John Prine can marvel listeners in the simplest of acoustic settings, with nothing more than a guitar and a song.In my mind, that’s the measure of a gifted songwriter. From time to time, I stumble upon a new singer/songwriter whose work warrants comparison to the luminaries on this list.Right now, I have been spinning The Hanging Road, the latest release by Joseph Huber, quite a bit. Virtually nonstop, actually, and Huber’s songwriting has me comparing him to my favorites above.Huber spent time on the road with the .357 String Band and now has three solo albums to his credit. And when I say “solo,” I mean it. Huber writes all the tunes and plays all the instruments on his recordings. The songs on The Hanging Road certainly don’t suffer from Huber’s lack of company. Both his instrumental chops and songwriting skills are on fine display.Trail Mix recently caught up with Joseph to chat about LPs, iPods, and sweet sounding suitcases.BRO – We are featuring “The Hanging Road” on Trail Mix this month. What’s the story behind the song?JH – The story behind the tune is that I had the chorus, medley, and the final chorus line bouncing around in my head for a while, and then I went home to visit my folks and my father pulls out this old Time-Life book on the American Southwest. He tells me that the Cheyenne used to call the Milky Way the “Hanging Road” and that it was the place where souls go when they die. My old man said that was a good image and line for a song and that I should write a song called that. So . . . . I did. My father comes to me every time he hears something that sounds like a song, and sometimes it just works. So, this was a collaborative effort for sure. And, contrary to what some may think, this has nothing to do with a road where hangings take place. It’s just such a beautiful substitute for where most people would put “heaven” or “the heavens.”BRO – What songwriters are blowing your mind right now?JH – I jump around a lot, but at this exact moment, I’ve been listening to Willy Tea Taylor, of Good Luck Thrift Store Outfit, and Alynda Lee Segarra, from Hurry For The Riff Raff. Willy Tea knows how to make life feel simple and within our grasp. He’s truly a salt-of-the-earth sort of writer who narrows everything down into a world where you can clearly see what is important and necessary for a good life. Hurray For The Riff Raff is a band most folks know about by now. They’ve been putting out great albums for a long time, but this newest one really has some great tunes on it. They certainly don’t need my seal of approval, as they are already blowing up this year, but still . . . my two cents is that it’s really, really good.BRO – Favorite guilty pleasure when out on the road?JH – It’s probably less attractive to admit that passing by the flashing lights of a casino makes your stomach jump into your neck with joy. But if we are truly talking guilty pleasures, then I’ll have to honestly say roulette. Don’t judge me.BRO – When is the last time you fell ass backwards into a song and it just worked?JH – It’s a rare occasion when the mind just opens up and words just flow out, at least for me. Writing just the right phrase can be laborious at times. The wordiest “songwriter” song on the album is probably “Wanchese & Manteo.” I was reading a travel novel called Blue Highway, by William Least Heat-Moon, who traveled the American landscape back in the 70s by taking nothing but off the beaten path back roads. He talked about visiting these coastal towns and the Indian chiefs associated with their towns’ names. The towns and the chiefs were strange microcosms and macrocosms of each other in a way that immediately made me circle the page and write, “This is a song” at the top. After finishing the book, I came back to that page and wrote every line in that song in a day. I reorganized it into a coherent whole and BAM!! It’s a beautiful day when the words just come, and that day was one of them. It’s certainly no radio hit due to its inherent style, but I am certainly proud of it.BRO – LPs or iPods?JH – Why dost thou sow seeds of division amongst my brethren? Ha! No, there’s room for both in my world, certainly. I’ve a soft spot in my heart for LPs and I will probably continue to press my albums on vinyl as long as I play music. But I’m a furniture maker who works in a filthy, dusty shop, and that’s where I do most of my music listening. So, iPods are absolutely necessary then. My records would be ruined pretty quick there. I like to think the world is moving toward a spot where these two formats will live happily together, like pressing LPs with download cards. I’m no predictor of the future, though.BRO – Any secrets to getting good tone out of a Samsonite suitcase?JH – Well, it was by no means on purpose that my two different suitcases I’ve used throughout my suitcase drumming career have been Samsonites. Both were found by my mother at various antique stores. Maybe she knew something about the “Samsonite Sound” before I did. But they both certainly have a great tone to them. From here on out, I’ll probably look for that name so I know it will be sturdy. And, as you can see, it’s a bit of a family affair here. My father comes up with the song titles, and my mother keeps my percussion section stocked.Joseph Huber will take to the road again in early August, with dates in Wisconsin, Minnesota, and Ohio. Late August finds Huber in Cookeville, Tennessee, for the Muddy Roots Music Festival.For more info on Joseph Huber and how to get a copy of The Hanging Road, surf over to www.josephhubermusic.com.