ScienceShot: The Saddest Spot in New York

first_imgIf you could look down from space and see the emotional state of every person in a city, what would it look like? We don’t have that technology yet, but Twitter is providing the next best thing. In a new study, researchers harvested every tweet that was geographically tagged to Manhattan and its surrounding boroughs during a 2-week period in April 2012. That was the easy part. The trick was deciphering the emotional content of those 604,000 utterances. Luckily, a large portion of tweets come with emoticons—for example, 🙂 and 🙁 for a smile or frown. By using these tweets as a training set, the team taught a computer to distinguish negative, positive, and neutral emotions. After projecting those emotions as colors on a map of New York City (pictured)—blue for positive, red for negative—the city’s mood landscape was suddenly revealed. Some of the patterns are no surprise. For example, people tended to be happiest near green areas such as Central Park and unhappiest around transportation hubs such as Penn Station and the entrance to the Midtown Tunnel. But the fine-grained details are striking. The closer people were to Times Square, the happier they got. And the city’s mood had a daily rhythm, mirroring that of the individuals who live and work there. People’s feelings—both positive and negative—were muted in the morning and peaked around midnight. The happiest place in Manhattan was Fort Tryon Park; the location is way uptown and thus takes effort to get to—the kind of effort people make when they’re enjoying a day off. The saddest? Hunter College High School. No surprise there. The data were collected the week students returned from vacation.last_img read more

Sarri rules out Hazard Madrid move: It’s impossible now!

first_imgMaurizio Sarri has revealed that Eden Hazard is happy at Chelsea and insisted that it would be “impossible” for him to leave for Real Madrid at this stage.The Belgian has long been on Madrid’s radar as Julen Lopetegui considers finding a replacement for Cristiano Ronaldo, who left for Juventus earlier in the summer transfer window.Thibaut Courtois has already made the move from Stamford Bridge to Spain, and has insisted that it would be “fantastic” if Hazard were to join him in Madrid. Editors’ Picks Man Utd ready to spend big on Sancho and Haaland in January Who is Marcus Thuram? Lilian’s son who is top of the Bundesliga with Borussia Monchengladbach Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! Goal understands that a contract offer is on the table for Hazard – a figure of around £300k-a-week that would make him the highest-paid player in the club’s history – but he is not close to signing the new deal.Sarri, though, is adamant that his star man wants to remain at the club, revealing that, given he wouldn’t be able to sign a replacement now the Premier League window is closed, it’s “impossible” Hazard will be leaving.He told reporters: “I think it’s impossible. It’s impossible because, here, the market is closed. We cannot change important players now, so I think it’s impossible.”Hazard is with us. I have spoken with him three or four times for everything, and he never said something about the market. So I think he is very happy to stay here.When asked about a new deal for Hazard, Sarri added: “I don’t want to discuss about contracts. It’s not my job. My job is on the pitch, to improve my players.”My job is to try to win matches. It’s not to sign new contracts. But I have seen a player who is very happy to stay here, so I think it will be no problem, the new contract.”Regarding Courtois’s departure, Sarri suggested there were “personal reasons” involved in the goalkeeper’s decision to leave and that, following the arrivals of Mateo Kovacic and Kepa Arrizabalaga, his squad is “complete”.He added: “I am very happy. Courtois’ situation was clear, he wanted to go to Madrid. There were some personal reasons. I don’t know really.”But we bought a young goalkeeper, one of the most important in Europe. I am really happy. And to Kovacic, because he has the characteristics for us. The squad is complete.”last_img read more

Young People Embarking on ‘A New Path’ to Economic Independence

first_img The ‘A New Path’ project, which began in January 2015, was scheduled to end in January 2017, but has been extended until September 2019. National Security State Minister, Senator the Hon. Pearnel Charles Jr., has hailed the ‘A New Path’ initiative as a movement that not only transforms the lives of beneficiaries but also guides them along a course of economic independence. ‘A New Path’ targets young people drawn from juvenile remand centres, State care facilities and the Citizen Security and Justice Programme (CSJP). Story Highlights National Security State Minister, Senator the Hon. Pearnel Charles Jr., has hailed the ‘A New Path’ initiative as a movement that not only transforms the lives of beneficiaries but also guides them along a course of economic independence.‘A New Path’ targets young people drawn from juvenile remand centres, State care facilities and the Citizen Security and Justice Programme (CSJP).It aims to provide hope to marginalised young people who have come into conflict with the law by providing them with the requisite skills for reintegration in the society.Senator Charles made the remarks at the closing ceremony of the first Organization of American States (OAS) ‘Pitch It!: Learning and Investing in Your Future’ initiative at The Knustford Court Hotel in New Kingston on September 5.‘Pitch It!: Learning and Investing in Your Future’ is a part of the OAS ‘A New Path’ Initiative.Senator Charles urged the participants to be agents of change in their communities and not to be daunted by naysayers, while encouraging each youngster to “challenge yourself to always be better for yourself, your communities, for Jamaica and the world”.He lauded the sponsors, adding that the Ministry will continue to provide the requisite support to transform the lives of the participants.For her part, President, Junior Achievement Jamaica, Alphie Mullings-Aiken, said while the initiative focused solely on those in State care facilities and remand centres, the project aims to empower youth to own their personal economic success.She indicated that 111 youth were engaged in a two-day training exercise, after which 51 were assessed during a week-long residential programme at the University of the West Indies. Additionally, she said they benefited from the Junior Achievement Company of Entrepreneurs training.“Each of the 51 attendees pitched their (business) proposal to a panel of judges. As the dust settled, 21 were awarded through the generous support of the United States Agency for International Development (USAID), Organisation of American States, the Trust for the Americas and Jamaica Money Market Brokers (JMMB) with an opportunity to start their own business,” she said.Mrs. Mullings-Aiken further informed that the other 30 participants received three-month work internships with local companies, adding that many are still employed.In her remarks, OAS Country Representative for Jamaica, Jeanelle van Glaanen Weygel, urged the participants to use their experiences to inspire others.The young people, drawn from juvenile remand centres, State care facilities and CSJP were awarded start up grants to begin their business ventures.Those established included engagements in photography, food and beverage and clothing retail, electrical and computer repair, tailoring, poultry farming and entertainment.The ‘A New Path’ project, which began in January 2015, was scheduled to end in January 2017, but has been extended until September 2019.The programme offers and facilitates weekly counselling, the implementation of educational and vocational training, conflict-resolution programmes as well as opportunities for apprenticeship and internship.It also includes a music programme in collaboration with the National Youth Orchestra, and a sports aspect facilitated by the Youth for Development Network.last_img read more

US UK EU must not interfere in our internal affairs China

first_imgBeijing: China on Tuesday warned the US, the UK and the EU against sending any “misleading signals” to the “ultra-radicals” who violently attacked the legislature in Hong Kong, saying Beijing strongly opposes their “gross interference” in the country’s internal affairs. A group of protestors on Monday broke through the Legislative Council (LegCo) building in Hong Kong and occupied it for several hours. They damaged the building and the furniture inside. Also Read – Turkey preparations for Syria offensive ‘completed’The violence followed weeks of mass protests over a controversial extradition law, which the locals apprehend could be used to send political dissidents from Hong Kong to mainland China for prosecution. Hong Kong, a former British colony, became a Special Administrative Region of China in 1997, when Britain’s 99-year lease expired. The city is governed under the principle of “one country, two systems”, under which China has agreed to give it some autonomy and preserve its economic and social systems for 50 years from the date of the handover. Also Read – Imran Khan arrives in China, to meet Prez Xi JinpingHong Kong Chief Executive Carrie Lam, who came under intense criticism at home and abroad, had put off plans to pass the controversial legislation and apologised but the protests continued, calling for its complete withdrawal and her resignation. July 1 marks the 22nd anniversary of the handing over of Hong Kong to China by the UK in 1997. China is in quandary over the continued pro-democracy mass protests which at time drew over two million people onto the streets. Beijing has blocked all references to Hong Kong protests in the vast social media networks to minimise the political impact of such protests in the mainland. Reacting to Monday’s protests, a spokesman of China’s Hong Kong and Macao Affairs Office here termed the protestors who attacked the LegCo as “ultra-radicals” and strongly condemned it. The spokesperson expressed firm support for the HKSAR (Hong Kong Special Administrative Region) government and police handling of the incident, and for holding the violent offenders criminally accountable in accordance with the law, state-run Xinhua news agency reported. “July 1 is a day of great festivity for people from all walks of life in Hong Kong to commemorate the return of Hong Kong to the motherland and the establishment of the HKSAR. “Some ultra-radicals, however, under the excuse of opposing the HKSAR government amending related ordinances, stormed the LegCo complex in an extremely violent manner and wantonly damaged facilities there,” the spokesperson said. “Seriously violating the law, the act tramples the rule of law in Hong Kong, undermines social order and the fundamental interests of Hong Kong, and is a blatant challenge to the bottom line of ‘one country, two systems’,” the spokesperson said, adding that “we strongly condemn this act”. The Chinese Foreign Ministry meanwhile spoke strongly against the US, the UK and the EU, issuing statement backing peaceful protests in Hong Kong. “I would like to reiterate that Hong Kong is a Special Administrative Region of China and its affairs are purely domestic. We deplore and strongly oppose the relevant countries’ gross interference in China’s internal affairs,” Chinese Foreign Ministry spokesman Geng Shuang told reporters. The US, the UK and the EU said the people of Hong Kong should have right to peaceful protests but urged them to refrain from violence and exercise restraint. “We advise relevant countries to exercise caution in their words, deeds and stop interfering in Hong Kong’s internal affairs in any form and do not in any form support those engaged in violence and break the law. Do not send any misleading signals or make any wrong moves,” he said. Asking how they would have reacted to such incidents if it happened in their countries, Geng said, “let us just think, if such violent behaviours happened in the US, the UK and the EU, what will they do with it. Will they just allow it to happen without doing anything”. “Now similar things happen in Hong Kong, they don’t condemn violence but instead they only want to make criticism and lecture all about peaceful protests and prevention of violence. This is double standards itself and ugly act, hypocrisy. I would like to reiterate that Hong Kong is a Special Administrative Region under China its affairs are purely domestic. “We deplore and strongly oppose the relevant countries gross interference in Hong Kong and China’s internal affairs. We once again urge the relevant countries to exercise caution in their words and deeds and don’t interfere in our internal affairs,” he added.last_img read more

Biz can use IGST credit to settle tax dues CBIC

first_imgNew Delhi: Businesses that have accumulated Integrated GST (IGST) credit in their books can settle it against central and state tax dues in any proportion, the revenue department has said. Importers typically pay IGST on goods they bring into the country. Also IGST is paid on inter-state movement of goods. This tax is supposed to be set-off against the actual GST paid, or may be claimed as refund in certain cases. The Central Board of Indirect Taxes and Customs (CBIC) in March had allowed utilisation of input tax credit (ITC) of IGST towards the payment of Central GST and State GST, in any order subject to the condition that the entire IGST liability has been first discharged using the accumulated credit. Also Read – Thermal coal import may surpass 200 MT this fiscalHowever, there were confusion among taxpayers regarding the quantum of utilisation of IGST credit in paying CGST and SGST dues. The CBIC has now clarified that the IGST credit can be used in payment of CGST or SGST in any order or proportion. Under Goods and Services Tax (GST), the tax levied on consumption of goods or rendering of service is split 50:50 between the centre (CGST) and the state (SGST). On inter-state movement of goods as well as imports, an IGST is levied, which accrues to the centre. Also Read – Food grain output seen at 140.57 mt in current fiscal on monsoon boostIdeally, there should be ‘nil’ balance in the IGST pool at the end of a fiscal since the amount should be used for payment of CGST and SGST. As some businesses are ineligible to claim the benefits of input tax credit (ITC), the balance gets accumulated in the IGST pool. AMRG and Associates Partner Rajat Mohan said, “This clarification from government would help businesses and taxpayers to swim out of the gap created between legal framework and GST network, now taxpayers can continue to work according to the functionality of GSTN without worrying for any legal consequences.” EY Tax Partner Abhishek Jain said, “This was a much needed clarification as this should help bring to rest the varied interpretation apprehended by industry on the utilisation of IGST credit”.last_img read more

Plant mutation could boost crop yields and help tackle food crisis –

“At a time when the world is facing a food and energy crisis of unprecedented proportions, plant mutation breeding can be a catalyst in developing improved, higher-yield, saline-resistant, sturdier crop varieties,” Werner Burkart, Deputy Director General of the International Atomic Energy Agency (IAEA), told a conference that opened at the Agency’s headquarters in Vienna today.The International Symposium on Induced Mutations in Plants brings together over 600 scientists, researchers and plant breeders from around the world to discuss the latest innovations and how they can improve crop varieties in the future. Mr. Burkart, who is Head of the Agency’s Department of Nuclear Sciences and Applications, said 2008 will be remembered as the year in which the world understood the realities of climate change, the food crisis and the energy debate in its link to hunger.“These big issues are intimately interlinked, and translate in the agronomy field into a competition between food, feed and fuel for soil, water, human and financial resources,” he noted.He pointed out that plant mutation has been used for more than 80 years, with mutagens such as X-rays, gamma radiation and chemicals having been used to produce plant varieties that are disease-resistant or best suited to conditions such as high altitude or saline soil.One success story is mutant barley varieties that thrive at altitudes of up to 5,000 metres in the highlands of Peru and which led to a 52 per cent increase in yields between 1978 and 2002. The IAEA has worked with radiation technology to induce mutation in plants since the 1960s and today the technology is being used worldwide. “Mutation induction has proven flexible, workable, and ready to use on any crop,” said Mr. Burkart, adding that it is a non-hazardous and low-cost technology that has the ability to address current challenges in agriculture. “The breeding of new mutant varieties – with a higher yield potential, more productive biomass for energy use, better nutrient composition for human health, better adaptation to climate change and variability, or a heightened potential to sequester carbon – will be the driving force to meet the challenges of the 21st century,” he stated.The four-day conference is a joint collaboration by the IAEA and the UN Food and Agriculture Organization (FAO), and the eighth of its kind. The first was held in 1969. 12 August 2008Plant mutation, a scientific technique that dramatically improves crop productivity, could be part of the solution to the current food and energy crisis that threatens to plunge millions worldwide into hunger, according to a United Nations expert on the subject. read more

Quality employment key to poverty alleviation UN official says

22 March 2010Decent employment opportunities are essential for countries to achieve economic growth and alleviate poverty, the head of United Nations Development Programme (UNDP) said today, stressing the need to create more and better jobs each year. Decent employment opportunities are essential for countries to achieve economic growth and alleviate poverty, the head of United Nations Development Programme (UNDP) said today, stressing the need to create more and better jobs each year.“Sustainable income generated through adult employment, for example, enables families to send their children to school,” said UNDP Administrator Helen Clark, addressing a session on the Social Dimension of Globalization in Geneva, organised by the International Labour Organization’s (ILO) governing body.“That then contributes to their children reaching their potential, and, therefore, to both a greater ability to participate fully in society in the future and in the workforce. That creates more resources for priority investments by families and nations. This is the kind of virtuous cycle which must be set in motion for development to gain traction,” she said.With only five years to go before the 2015 target for the achievement of the Millennium Development Goals (MDGs) of halving extreme poverty and hunger, the pace at which better jobs are created has to be stepped up, Miss Clark said.She lauded ILO’s Global Jobs Pact, saying UNDP’s executive board had in January resolved that the pact should be integrated into UNDP’s operational activities. The pact is designed to guide national and international policies aimed at stimulating economic recovery, generating jobs and providing protection to working people and their families.Miss Clark noted that globally, the number of people living in extreme poverty is estimated to have dropped from 1.8 billion people in 1990 to 1.4 billion in 2005. Enrolment in primary education has increased significantly, and the deaths of children under the age of five decreased significantly between 1990 and 2008.Yet many challenges remain, she said, pointing out that little progress has been made in maternal health. In the developing world as a whole, there were 480 maternal deaths per 100,000 births in 1990 compared to 450 deaths in 2005, and that small decline reflects progress only in some regions.Overall, the progress made on the MDGs has been uneven, Miss Clark noted. While in some countries the rate of extreme poverty reduction has met the Goal, in others, poverty rates are actually increasing. read more

President Sirisena holds talks with Modi and Solheim

Later, the President also met with Erik Solheim, the Executive Director of the United Nations Environment Programme.During this meeting, issues relating to the environmental conservation, weather and climate change and marine pollution were discussed and the President apprised regarding the specially designed programme to protect the environment of Sri Lanka. President Maithripala Sirisena after attending the Founding Conference of the International Solar Alliance (ISA) in New Delhi met with the Indian Prime Minister Narendra Modi at the Rashtrapati Bhavan.The Indian Prime Minister said that the participation of the Sri Lankan President in the ISA Summit is a privilege and requested the President to extend his assistance in delivering the message of the ISA Summit to the world. Mr. Eric Solheim appreciated the initiatives taken by Sri Lanka towards the protection on environment. During this meeting the relations between Norway and Sri Lanka was also recalled. The Indian External Affairs Minister, Minister Nimal Siripala de Silva and Ambassadors of both countries participated at the meeting. The Prime Minister recalled that during the past few years the relations between the two countries was further strengthened and pointed out in future it is important to strengthen these bilateral relations between the two countries economically as well. President Sirisena explained regarding the programmes implemented to increase the forest density from the current 28% to 32% and further said that the Air Force has launched special monitoring programme for the protection of forests, and once in two weeks the Air Force submit a report in this regard to him.The President further said about the steps that have been taken to control the use of plastic in Sri Lanka in a background where the marine pollution is a vast problem.The President pointed out the environmental issues arises as a result of excavating soil for construction activities and requested Mr. Eric Solheim to introduce technological alternatives and proposals in this regard to our country. read more

Motel 6 settlement over immigration calls clears hurdle

PHOENIX — A federal judge in Arizona has granted preliminary approval of a settlement in the case involving thousands of Motel 6 guests said to have had their privacy violated when the national chain gave their information to immigration authorities.The Mexican American Legal Defence and Educational Fund rights group sued Motel 6 in January 2018, saying that giving guests’ information to immigration agents without a warrant violated privacy and civil rights laws.The settlement proposes to make up to $10 million available for claims by members of the class action lawsuit.U.S. District Judge David Campbell had told attorneys for Motel 6 and MALDEF last month that he would approve the preliminary settlement if minor changes were made in the document.Campbell granted preliminary approval last Friday.The Associated Press read more

California Senator says Facebook should remove shoving video

SACRAMENTO, Calif. — A California state senator is criticizing Facebook for refusing to remove a video of an anti-vaccine protester shoving him in the back.Democratic Sen. Richard Pan said in a speech on the Senate floor on Thursday that Facebook is “deliberately giving a platform to violence.” He says he worries the video will incite others to violent acts.Representatives for Facebook did not immediately respond to a request for comment.Pan has authored several bills that seek to limit exemptions for child vaccinations that have prompted protests.On Wednesday, 54-year-old Kenneth Austin Bennet filmed his confrontation with Pan on the sidewalk near the state capitol. The video shows Bennett shoving Pan in the back.The Sacramento Police Department cited Bennet for misdemeanour assault and released him.The Associated Press read more

Android sera bientôt lOS mobile préféré des développeurs

first_imgAndroid sera bientôt l’OS mobile préféré des développeursD’ici un an, Android devrait devenir le système d’exploitation mobile préféré des développeurs, qui ne délaisseront toutefois pas leur numéro un actuel qu’est l’iOS d’Apple. C’est du moins ce qu’affirme une récente étude du cabinet d’analyse Ovum.Au cours des douze prochains mois, Android pourrait devenir la plate-forme préférée des développeurs, qui sont déjà de plus en plus nombreux à enrichir l’Android Market, aujourd’hui fourni de 400.000 applications dédiées aux mobiles équipés de l’OS de Google. C’est ce qu’affirme le cabinet d’analyses Ovum, dans une étude rapportée parÀ lire aussiMaladie de Charcot : symptômes, causes, traitement, où en est on ?Mais les développeurs ne cesseront pas pour autant de travailler pour les terminaux iOS d’Apple. La plupart d’entre eux continueront de se consacrer aux deux plate-formes, simultanément. Toutefois, ils donneront la priorité à celui de Google, souligne le cabinet. Les développeurs s’intéresseront en outre de plus en plus à deux autres systèmes d’exploitation, BlackBerry OS et Windows Phone, affirme l’étude. Le partenariat de Microsoft et Nokia, dont les Windows Phone Lumia se seraient déjà vendus à 1,3 million d’exmplaires, a visiblement séduit les développeurs qui se sentent près à miser sur l’OS dont l’avenir divise les experts. Pour l’heure, moins de deux ans après son lancement, le Windows Marketplace compte 60.000 applications. En 25 jours seulement, il s’est enrichi de 10.000 applis.Le 28 janvier 2012 à 15:00 • Emmanuel Perrinlast_img read more

Severe Flooding from Joaquins Rains shuts down Provo

Severe Flooding from Joaquins Rains shuts down Provo

first_imgFacebook Twitter Google+LinkedInPinterestWhatsApp Related Items:flooding, hurricane joaquin Louis Bacon’s Moore Bahamas Foundation Announces Donation To Rotary Club Of The Bahamas For Relief Efforts In The Bahamas Providenciales, 02 Oct 2015 – The country was not under storm watch or warning, but that did not stop Hurricane Joaquin from bringing the country to a standstill. Airports were closed, airline companies grounded flights, schools and banks were shut down and government required only essential personnel. In Provo and Grand Turk photos revealed that roadways and businesses were flooded;traffic at an impasse and power was out in areas like South Dock and Chalk Sound. AsHurricane Joaquin moves away from TCI and further toward the Central and Northwestern Bahamas, it is a Category three hurricane, with 120 mph winds, expected to dump as much as 30 inches of rain. Atlantic Hurricane Season over; takes 88 lives, costs $590 millioncenter_img North to Middle Caicos Causeway behind schedule; residents concerned over Joaquin flooding Facebook Twitter Google+LinkedInPinterestWhatsApp Recommended for youlast_img read more

Khaleda to be freed soon Moudud

Khaleda to be freed soon Moudud

first_imgBNP senior leader Moudud Ahmed. Prothom Alo File PhotoBNP senior leader Moudud Ahmed on Wednesday expressed the hope that their imprisoned party chairperson Khaleda Zia will be freed soon on bail and lead a democratic movement in the country, reports UNB.“I’d earlier said she (Khaleda) would get bail by a week, and she was granted bail in two cases by the time. We’re now waiting to get bail for her in two more cases as we’re trying to free her through a legal process,” he said.Speaking at a seminar, the BNP leader further said, “Khaleda Zia will return among us very soon by getting freed on bail, and she’ll lead the democratic movement. The rule of law and democracy will be restored in Bangladesh under her leadership.”BNP arranged the programme at the Institution of Engineers, Bangladesh marking the international day in support of victims of torture.Moudud, a BNP standing committee member, said Khaleda is being repressed as she has been kept in jail for over 15 months in a ‘false and fake’ case.He alleged that their party leaders and activists have been going through serious repression over the last 10 years. “I think it won’t be possible to eliminate BNP through repressive acts. This government has rather established BNP to remain for the next 100 years through its repression.”The BNP leader said those who were subjected to repression over a decade will never support Awami League.Speaking at the programme, BNP secretary general Mirza Fakhrul Islam Alamgir stressed the need for forging a strong unity of people to oust the current ‘autocratic’ regime. “The strength of people’s unity is the only way to defeat those who want to establish one-party rule and cement power for long time. That’s why we badly need to forge the people’s unity.”Apart from people’s unity, he said, political parties, intellectuals and human rights activists also must get united to get rid of the ’misrule’ of the current ‘despotic’ government.Fakhrul said their leaders and activists were repressed, but they were not mentally defeated. “We’ll defeat the government through a united movement.” He alleged that the way their party leaders and activists were repressed over the last 12/13 years is unprecedented in the world.The BNP leader said many of their party leaders and activists alongside Khaleda Zia have been kept in jail as the government wants to cement the ‘one-party’ rule in the country.He said their main demand is now to have their chairpersons freed from jail. “Then we demand holding a fresh election immediately under a non-party government. We think a fresh credible election is the only way to resolve the current political problem.”At the beginning of the seminar, a documentary was screened depicting the torture and repression on BNP leaders and activists.Some victims, who were made disappeared and repressed and rape at different times, narrated their bad and painful experiences at the programme.Some foreign diplomats stationed in Dhaka, including representatives from the UK, Australia, India, Japan and UNDP, were present at the event.last_img read more

Super Talent Introduces a 128Gb SSD for Under 300

Super Talent Introduces a 128Gb SSD for Under 300

first_imgIf you have been waiting for the price of Solid State Drives (SSD) to come down in price, the time has finally come. Super Talent has introduced their 128Gb, 2.5-inch, SATA II “MasterDrive LX” for the affordable price of $299. This works out to about $2.49 per gigabyte. If that´s still too much money, then you can go for the 64Gb version that sells for $179. Super Talent´s MasterDrive SSDs offer five times better resistance to shock and vibration, consumes less power, supports a wider range of operating temperatures and altitudes, and are completely silent. Super Talent´s MasterDrive SSDs is backed by a 1-year warranty. The MasterDrive LX is built with NAND flash and uses a SATA-II 3Gbps interface that makes it 100% interchangeable with hard disk drives. These SSDs support sequential read speeds of up to 100 MB/sec, and sequential write speeds of up to 40 MB/sec. Integrated ECC, wear leveling and bad bit management functions dramatically improve the reliability and lifespan of these SSDs.The FTM64GO25H model is Super Talent´s 64GB 2.5-inch SATA-II SSD with a read/write speed of 100/40 MB/sec and sells for $179. The FTM28GO25H is Super Talent´s 128GB 2.5-inch SATA-II SSD with a read/write speed of 100/40 MB/sec and sells for $299. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img Citation: Super Talent Introduces a 128Gb SSD for Under $300 (2008, September 30) retrieved 18 August 2019 from read more

Many Families With High Breast Cancer Risk Await a Genetic Explanation

Many Families With High Breast Cancer Risk Await a Genetic Explanation

first_imgFor decades, Piri Welcsh has had professional and personal stakes in understanding the genetics of breast cancer.In the 1990s, the molecular geneticist participated in an international race to clone BRCA1, the first gene linked to breast cancer risk, and she works to this day in the lab of pioneering breast cancer geneticist Mary-Claire King at the University of Washington.And then there’s Welcsh’s own family. Her grandmother died of breast cancer, her mother is a breast cancer survivor, and her aunt was just diagnosed with breast cancer.Since the days of the BRCA1 discovery, researchers have identified more than 100 genes that, in certain forms, raise breast cancer risk. And yet that still leaves many people with elevated familial risk seeking answers. “Some families, like mine, are unsolved,” says Welcsh, who is vice president of education for the support group FORCE: Facing Our Risk of Cancer Empowered. “They seem to have something genetic being passed through generations, yet no mutation identified.”Researchers hope to offer explanations to many women like Welcsh by broadening their knowledge of the genes and gene variants involved in breast cancer risk through a focus on tiny DNA differences between one person’s genome and the next — variants known as SNPs, or single nucleotide polymorphisms. By so doing, they aim to come to a better understanding of the causes of breast cancer and develop more comprehensive screening panels — and, down the road, perhaps new and more bespoke treatments.Light-microscope image of a dividing breast cancer cell, showing chromosomes (blue), the mesh of tubules that pull the chromosomes to the poles (red) and mitochondria (green). (Credit: National Cancer Institute/ University of Pittsburgh Cancer Institute)Familial MysteriesThere are more than 3 million women in the US with a history of breast cancer, and an additional 266,120 cases are expected to be diagnosed this year. Non-genetic risk factors such as reproductive and menstrual history are well established and account for the lion’s share of breast cancer cases, which are mostly sporadic. But about 5 to 10 percent of breast cancers are genetic. Most of them are linked to variants of the breast cancer genes BRCA1 and BRCA2, while another few percent are linked to variants in other genes.An additional 15 to 20 percent of women with breast cancer have a family history of the disease — with two or more first- or second-degree relatives who have been diagnosed with breast cancer — but no genetic cause yet identified.To try to understand where the heightened risk is coming from in this so-called “familial” category, in recent years researchers have turned to GWAS (genome-wide association studies) — technology that scours people’s genomes to find SNP variations that are more frequent in people with breast cancer than those without it. This, in turn, can identify genes involved in risk.So far, more than 150 SNPs have been associated with breast cancer. The vast majority of these appear to increase risk by just a fraction of a percent (compared with up to 70 percent for certain BRCA variants, and on the order of 10 percent for other known variants in other genes). But if many such SNPs were present in the same person’s genome, their effect could add up to significant risk, researchers say.Most of these minor variants lie not within the core of a gene itself but in regulatory areas that determine how and when a gene is turned on and off, according to a 2017 report by an international group of researchers called the OncoArray Consortium. The group surveyed DNA data from more than 100,000 women of European and East Asian ancestry who had breast cancer and compared them with a similar number of cancer-free individuals, identifying 65 new genome regions associated with breast cancer risk.This pie chart illustrates the proportion of breast cancer cases that run in families, compared with sporadic cases. Cases rooted in genetics are divided into two categories based on the strength and pattern of inheritance. The “hereditary” class is reserved for cases of breast cancer that are inherited with an autosomal dominant pattern — meaning that the trait passes along as if it were a dominant gene located on the non-sex chromosomes. The well-known BRCA1 and BRCA2 gene variants are examples.There are likely many more to be identified, says study coauthor Montserrat García-Closas, an epidemiologist at the National Cancer Institute. GWAS studies can pick up only the highest signals — variants contributing the greatest effects — but don’t detect ones below a certain threshold, she says. More precisely, the OncoArray authors calculated that the variants they could detect explain just 18 percent of the elevated breast cancer risk seen in women in the familial class, while ones below the threshold could explain an additional 23 percent.New VariantsIdentifying these new variants is important for several reasons, oncologists say. First of all, it provides patients and their doctors the approximate risk of a woman developing breast (and often other) cancers. In some cases, it gives physicians information about the biology of a patient’s cancer and can be used to devise screening protocols, prevention tactics and treatment methods.A growing number of gene variants have been linked to an elevated risk of breast cancer. Risk can be raised by different amounts depending on the specific variant of a given gene that a person carries. To understand the many inherited cases that remain unexplained, scientists are turning to tiny, single-letter differences known as SNPs. Though each SNP may raise risk only slightly, a combination of several may as much as double risk if they affect the same, or related, biochemical pathways.Recently, commercial labs such as Myriad Genetics and Ambry Genetics began offering to test for certain SNP variants when running the traditional panel of known breast cancer genes. This may be jumping the gun, says García-Closas — because studies calibrating and validating how much these variants elevate risks are still underway and it could be three to five years before they’re strongly validated. “I would take, with a little grain of salt, the value of the current risk scores available,” she says. “I think this is still in the early stages and I think they will get better.”Before physicians decide to use variants in panels, they generally want to know that those variants are adequately understood, raise disease risk by a significant enough amount and make a tangible difference to clinical management, adds Katherine Nathanson, a clinical geneticist at the University of Pennsylvania’s Perelman School of Medicine.“BRCA1 and BRCA2, for example — we’ve known about them for a long time, we really know what kind of risks they are associated with, we know how to interpret those mutations,” she says. “But there are genes that have been more recently described, or for which we don’t fully understand what the cancer risks are, or the risks are lower, but are also sort of grouped together on those panels.”Breast Cancer ScreeningOnce such facts are solidified, including them in a panel may be an asset to at-risk women seeking health insurance coverage for additional breast cancer screening. The National Comprehensive Cancer Network has guidelines for managing women who carry genetic variants identified through panels, including more frequent breast exams and more sensitive screening methods such as breast MRIs. Individuals at especially high risk may be offered prophylactic interventions such as mastectomy or chemoprevention drugs like tamoxifen.But the identified risk has to be high enough and established before insurance companies will pay for such treatments, says Rachel Shapira, a genetic counselor at UCLA Health in Los Angeles. Companies generally require a lifetime risk score — derived from genetic tests or family history assessments such as the Tyrer-Cuzick risk model — of over 20 percent before covering annual breast MRIs in addition to annual mammograms. And many SNPs are too new for there to be clinical or insurance guidelines that address them.Typical of the questions getting bounced around, Shapira says, is “if I have a patient — their Tyrer-Cuzick score is 16 percent, but their risk score with SNPs is 30 percent — will their insurance pay for anything? And we don’t know yet.”There are millions of places in the human genome where a DNA letter can vary from one person to the next. These differences are known as SNPs (single nucleotide polymorphisms). Researchers are looking for SNPs linked to an elevated risk of breast cancer in order to help explain cases where breast cancer runs in families but no genetic cause is yet known. In this example, Person 1 has a SNP that has been linked to elevated breast cancer risk in population studies; the other two individuals have SNPs that are not.Scientists are continuing to study identified breast-cancer-linked SNPs and find new ones with smaller effects. Since some SNPs might not, individually, raise breast cancer risk by much, homing in on risk-raising combinations could be key, says Chad Myers, a computational biologist at the University of Minnesota. Such studies aren’t easy because they require very large groups of women, he says. “For each person, you have 500,000, sometimes one million, different SNPs you measure. That’s like a half-trillion combinations to look at.”Pathways for RiskMyers and his team tried a more systematic approach. They chose to study sets of genes that are known to work together in the same or related biochemical pathways. The idea is this: Say that disrupting a certain pathway raises breast cancer risk. In that case, individual SNPs in genes in that pathway might compromise it only slightly. But when several different SNPs affecting the pathway at different spots occur together in the same genome, they could damage it significantly. And because the human body has lots of redundancies — a physiological need can often be met by more than one biochemical pathway — several SNPs that impair two related pathways might similarly carry a lot of clout.In a 2017 study of nearly 8,000 women with breast cancer and more than 8,500 without, Myers and his colleagues did, indeed, find evidence that combinations of SNPs within one pathway, and especially two related pathways, can raise the breast cancer risk significantly above what a single SNP could do — roughly doubling lifetime risk in some cases, Myers estimates. The study pinpointed 25 biochemical pathways involved in breast cancer risk, 16 of which had never before been implicated. These could therefore provide new insights into the mechanisms behind increased risk.Researchers are just in the early stages of understanding what all these SNPs do to raise breast cancer risk. Will they ultimately offer answers to people like Welcsh, who still hopes to find her genetic link so the family can plan preventive actions? Welcsh wonders about that. “It could be that just in my family, there is a mutation in a gene, [and] that no one else in the world has a mutation in that gene – it could be unique to one family,” she says.But others are more hopeful that SNPs stand to open new doors to understanding. “We’re just scratching the surface,” Nathanson says.This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.last_img read more

Samsung Galaxy S10 S10 300 Off for Prime Day 350 Off Note

Samsung Galaxy S10 S10 300 Off for Prime Day 350 Off Note

first_img Share Tweet Submit Samsung has discounted its flagship lineup for Prime Day 2019 and the deals are absolutely red hot.The Galaxy S10 and Galaxy S10+ are the real stars in the Android world right now thanks to their amazing displays, wonderful cameras and sleek new design. All of that comes at a pretty high price but Samsung is aiming to put the smartphones in everyone’s hand this Prime Day 2019 by slashing the price by $300 on both models. If that doesn’t sound too appealing to you, then you will be pleased to learn that you can pick up a Galaxy Note 9 instead at a $350 discount. Still not convinced? How about a Galaxy S9+ with a $250 discount? We knew it will catch your attention at some point. Let’s dive straight into the available deals.Buy Samsung Galaxy S10 Factory Unlocked Phone with 128GB – Was $899.99, now just $599.99Buy Samsung Galaxy S10+ Plus Factory Unlocked Phone with 128GB (U.S. Warranty) – Was $999.99, now just $699.99Buy Samsung Galaxy Note 9 Factory Unlocked Phone with 6.4″ Screen and 128GB – Was $999.99, now just $649.99Buy Samsung Galaxy S9+ Factory Unlocked Smartphone 64GB – Was $699.99, now just $449.99All of the smartphones above are commitment-free and fully unlocked, allowing you to use them on any carrier of your choice. Make use of the deals today if you want to get hold of the best smartphone in the business in terms of display tech.last_img read more

Implementing hashing algorithms in Golang Tutorial

first_imgA hashing algorithm is a cryptographic hash technique. It is a scientific calculation that maps data with a subjective size to a hash with a settled size. It’s intended to be a single direction function, that you cannot alter. This article covers hash functions and the implementation of a hashing algorithm in Golang. This article is taken from the book Learn Data Structures and Algorithms with Golang by Bhagvan Kommadi. Complete with hands-on tutorials, this book will guide you in using the best data structures and algorithms for problem-solving in Golang. Install Go version 1.10 for your OS. The GitHub URL for the code in this article is available here. The hash functions Hash functions are used in cryptography and other areas. These data structures are presented with code examples related to cryptography. There are two ways to implement a hash function in Go: with crc32 or sha256. Marshaling (changing the string to an encoded form) saves the internal state, which is used for other purposes later. A BinaryMarshaler (converting the string into binary form) example is explained in this section: //main package has examples shown// in Hands-On Data Structures and algorithms with Go bookpackage main// importing bytes, crpto/sha256, encoding, fmt and log packageimport ( “bytes” “crypto/sha256” “encoding” “fmt” “log” “hash”) The main method creates a binary marshaled hash of two example strings. The hashes of the two strings are printed. The sum of the first hash is compared with the second hash using the equals method on bytes. This is shown in the following code: //main methodfunc main() { const ( example1 = “this is a example ” example2 = “second example” ) var firstHash hash.Hash firstHash = sha256.New() firstHash.Write([]byte(example1)) var marshaler encoding.BinaryMarshaler var ok bool marshaler, ok = firstHash.(encoding.BinaryMarshaler) if !ok { log.Fatal(“first Hash is not generated by encoding.BinaryMarshaler”) } var data []byte var err error data, err = marshaler.MarshalBinary() if err != nil { log.Fatal(“failure to create first Hash:”, err) } var secondHash hash.Hash secondHash = sha256.New()var unmarshaler encoding.BinaryUnmarshaler unmarshaler, ok = secondHash.(encoding.BinaryUnmarshaler) if !ok { log.Fatal(“second Hash is not generated by encoding.BinaryUnmarshaler”) } if err := unmarshaler.UnmarshalBinary(data); err != nil { log.Fatal(“failure to create hash:”, err) } firstHash.Write([]byte(example2)) secondHash.Write([]byte(example2)) fmt.Printf(“%x\n”, firstHash.Sum(nil)) fmt.Println(bytes.Equal(firstHash.Sum(nil), secondHash.Sum(nil)))} Run the following command to execute the hash.go file: go run hash.go The output is as follows: Hash implementation in Go Hash implementation in Go has crc32 and sha256 implementations. An implementation of a hashing algorithm with multiple values using an XOR transformation is shown in the following code snippet. The CreateHash function takes a byte array, byteStr, as a parameter and returns the sha256 checksum of the byte array: //main package has examples shown// in Go Data Structures and algorithms bookpackage main// importing fmt packageimport (“fmt””crypto/sha1″”hash”)//CreateHash methodfunc CreateHash(byteStr []byte) []byte {var hashVal hash.HashhashVal = sha1.New()hashVal.Write(byteStr)var bytes []bytebytes = hashVal.Sum(nil)return bytes} In the following sections, we will discuss the different methods of hash algorithms. The CreateHashMutliple method The CreateHashMutliple method takes the byteStr1 and byteStr2 byte arrays as parameters and returns the XOR-transformed bytes value, as follows: // Create hash for Multiple Values methodfunc CreateHashMultiple(byteStr1 []byte, byteStr2 []byte) []byte { return xor(CreateHash(byteStr1), CreateHash(byteStr2))} The XOR method The xor method takes the byteStr1 and byteStr2 byte arrays as parameters and returns the XOR-transformation result, as follows: The main method The main method invokes the createHashMutliple method, passing Check and Hash as string parameters, and prints the hash value of the strings, as follows: // main methodfunc main() { var bytes []byte bytes = CreateHashMultiple([]byte(“Check”), []byte(“Hash”)) fmt.Printf(“%x\n”, bytes)} Run the following command to execute the hash.go file: go run hash.go The output is as follows: In this article, we discussed hashing algorithms in Golang alongside code examples and performance analysis. To know more about network representation using graphs and sparse matrix representation using a list of lists in Go, read our book Learn Data Structures and Algorithms with Golang. Read Next Go User Survey 2018 results: Golang goes from strength to strength, as more engineers than ever are using it at work. State of Go February 2019 – Golang developments report for this month released The Golang team has started working on Go 2 proposalslast_img read more

React Native 060 releases with accessibility improvements AndroidX support and more

first_imgYesterday, the team behind React Native announced the release of React Native 0.60. This release brings accessibility improvements, a new app screen, AndroidX support, CocoaPods in iOS by default, and more. Following are some of the updates introduced in React Native 0.60: Accessibility improvements This release ships with several improvements to accessibility APIs both on Android and iOS. As the new features directly use APIs provided by the underlying platform, they’ll easily integrate with native assistance technologies. Here are some of the accessibility updates to React Native 0.60: A number of missing roles have been added for various components. There’s a new Accessibility States API for better web support in the future. AccessibilityInfo.announceForAccessibility is now supported on Android. Extended accessibility actions will now include callbacks that deal with accessibility around user-defined actions. iOS accessibility flags and reduce motion are now supported on iOS. A clickable prop and an onClick callback are added for invoking actions via keyboard navigation. A new start screen React Native 0.60 comes with a new app screen, which is more user-friendly. It shows useful instructions like editing App.js, links to the documentation, how you can start the debug menu, and also aligns with the upcoming website redesign. CocoaPods are now part of React Native’s iOS project React Native for iOS now comes with CocoaPods by default, which is an application level dependency manager for Swift and Objective-C Cocoa projects. Developers are recommended to open the iOS platform code using the ‘xcworkspace’ file from now on. Additionally, the Pod specifications for the internal packages have been updated to make them compatible with the Xcode projects, which will help with troubleshooting and debugging. Lean Core removals In order to bring the React Native repository to a manageable state, the team started the Lean Core project. As a part of this project, they have extracted WebView and NetInfo into separate repositories. With React Native 0.60, the team has finished migrating them out of the React Native repository. Geolocation has also been extracted based on the community feedback about the new App Store policy. Autolinking for iOS and Android React Native libraries often consist of platform-specific or native code. The autolinking mechanism enables your project to discover and use this code. With this release, the React Native CLI team has made major improvements to autolinking. Developers using React Native before version 0.60, are advised to unlink native dependencies from a previous install. Support for AndroidX (Breaking change) With this release, React Native has been migrated to AndroidX (Android Extension library). As this is a breaking change, developers need to migrate all their native code and dependencies as well. The React Native community has come up with a temporary solution for this called “jetifier”, an AndroidX transition tool in npm format, with a react-native compatible style. Many users are excited about the release and considered it to be the biggest RN release. Other developers shared some tips for migrating to AndroidX, which is an open source project that maps the original support library API packages into the androidx namespace. We can’t use both AndroidX and the old support library together, which means “you are either all in or not in at all.” Here’s a piece of good advice shared by a developer on Reddit: “Whilst you may be holding off on 0.60.0 until whatever dependency you need supports X you still need to make sure you have your dependency declarations pinned down good and proper, as dependencies around the react native world start switching over if you automatically grab a version with X when you are not ready your going to get fun errors when building, of course this should be a breaking change worthy of a major version number bump but you never know. Much safer to keep your versions pinned and have a googlePlayServicesVersion in your buildscript (and only use libraries that obey it).” Considering this release has major breaking changes, others are also suggesting to wait for some time till 0.60.2 comes out. “After doing a few major updates, I would suggest waiting for this update to cool down. This has a lot of breaking changes, so I would wait for at least 0.60.2 to be sure that all the major requirements for third-party apps are fulfilled ( AndroidX changes),” a developer commented on Reddit. Along with these exciting updates, the team and community have introduced a new tool named Upgrade Helper to make the upgrade process easier. To know more in detail check out the official announcement. Read Next React Native VS Xamarin: Which is the better cross-platform mobile development framework? Keeping animations running at 60 FPS in a React Native app [Tutorial] React Native development tools: Expo, React Native CLI, CocoaPods [Tutorial]last_img read more

Four keys to understanding Costa Ricas upcoming elections

Four keys to understanding Costa Ricas upcoming elections

first_imgThe end of bipartisanshipThe 2014 presidential election, in which current President Luis Guillermo Solís from the Citizen Action Party (PAC) emerged victorious, marked the end of a bipartisan balance that dominated Costa Rican elections since the 1950s,Before that, power rotated fairly evenly between the PLN and its opposition, the Social Christian Unity Party (PUSC).“When bipartisanship existed, the decision was made beforehand because the population was divided between the two big parties. When this breaks, the elements with which people choose their candidates begin changing, other criteria emerge,” said Gustavo Araya, a political scientist from the Latin America’s Social Sciences Faculty.He added, “We’re in an undefined moment for the population.” Costa Ricans will head to the voting booth on Feb. 4 to choose their next president and 57 members for the Legislative Assembly – and polling trends suggest that a significant percentage of them will make their final decisions just weeks, days, or possibly hours before they make their mark on history.The following are four key elements to understanding the electoral process in Costa Rica, where 3.2 million people will be eligible to choose among 13 candidates for the presidency.Open electionOpinion polls show that close to 30 percent of the electorate is still undecided in the final stretch of the contest.An OPol survey for the internet news site, published on Jan. 16, showed that 28.2 percent of those consulted have not decided who to vote for.That poll put the two front-runners in a dead heat, well within the margin of error: Antonio Álvarez Desanti, a former Cabinet minister and legislator from the National Liberation Party (PLN), was in the lead with 14 percent, closely followed by the criminal defense attorney Juan Diego Castro, a former Security and Justice Minister, with 13.5 percent. Castro has led the field in recent polls from other sources. Costa Rica’s elections 2018: a primer Costa Rica approaches presidential elections with an uncertain scenario How Juan Diego Castro is turning Costa Rica upside down Neither candidate appears anywhere near the 40 percent minimum required to win in the first round of voting. If no one crosses that mark, the country would head to a second round on April 1.OPol’s poll was conducted from Jan. 9-11 with a sample size of 2,875 people and a margin of error of 1.8 points.“The candidates who are in first and second place are within reach of those who are in fourth or fifth place,” said political scientist Alberto Cortés from the University of Costa Rica. “This reflects an electoral behavior pattern with a high degree of volatility.” Chinese cementSomething similar happened with Juan Diego Castro, from the tiny National Integration Party (PIN), whose law-and-order, “mano dura” rhetoric has allowed him to capitalize the indignation provoked by a scandal about the importation of Chinese cement, which exposed a traffic of influences network in the three powers of the estate.According to analyst Gustavo Araya, this topic, which dominated headlines in late 2017, carries significant weight with the voters, but the candidates must vary their talking points in these final weeks because the cement scandal “already happened. It’s gone.”center_img Costa Rica calls for compliance with international court ruling on gay marriage Gay marriageWith this volatile scenario, breaking news has influenced voters’ thinking. One example: the Inter-American Court of Human Rights’ ruling on Jan. 9 that member states, includign Costa Rica, must recognize same-sex marriage.In response, the evangelical legislator and presidential candidate Fabricio Alvarado said that should he win the presidency, he’d withdraw Costa Rica from the Inter-American Court of Human Rights.Social media analyst Esteban Mora reported that from Jan. 9-14, Alvarado registered an increase of 122 percent in the number of followers of his Facebook page, with an exponential spike in his social media interactions. The real reason the ‘cementazo’ is so scary for Costa Rica – and so important Facebook Comments Related posts:Costa Rica’s elections 2018: a primer Six weeks before elections, one third of Costa Ricans are undecided Christiana Figueres: ‘Costa Rica is in danger of losing what it’s gained’ Presidential candidate Fabricio Alvarado pulls out of UCR debatelast_img read more