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AstraZeneca has expanded its agreement with cell therapy firm Oxford Biomedica to mass-produce its COVID-19 potential vaccine, as it looks to scale-up supply ahead of a possible US fast-track approval.While the British drugmaker works on the widely watched coronavirus vaccine hopeful, AZD1222, its main portfolio of treatments for cancer, diabetes and heart diseases scored a win after its drug, Imfinzi, was approved for use in Europe to treat an aggressive form of lung cancer.The company’s shares gained as much as 1.5% to trade at 84.6 pounds by 0807 GMT, outperforming the benchmark FTSE-100 index, after Oxford Biomedica announced the expanded agreement and on news of the EU approval for Imfinzi. Cambridge-based AstraZeneca’s vaccine is among the leading candidates in the global race for a successful vaccine and it has entered late-stage trials in the United States, the company said on Monday, as it targets 3 billion doses of the vaccine, globally.Oxford Biomedica said in a statement that AstraZeneca would give it 15 million pounds ($20 million) upfront to reserve manufacturing capacity at Oxford Biomedica’s plant and that it could get an additional 35 million pounds under a new 18-month deal.The company was spun off in 1995 from the University of Oxford, which developed the vaccine before licensing it to AstraZeneca in April.It was among AstraZeneca’s initial partners when they teamed up to produce the vaccine and focus on UK and European supply. Tuesday’s deal could be expanded further by another 18 months into 2022 and 2023, Oxford Biomedica said, sending its share price up 2.1% to 862 pence. “Our previously announced partnership with the UK’s Vaccine Manufacturing Innovation Centre [VMIC] has supported our ability to make additional facilities available for this supply agreement,” said Oxford Biomedica’s Chief Executive John Dawson.The company, however, did not specify how many doses of AstraZeneca’s vaccine it expects to produce under the expanded deal, which is for “large-scale commercial manufacture,” according to its statement. Topics :
Moody’s: Pennsylvania’s Outlook Remains Negative, Warns of Consequences of Failing to Address Structural Budget Gap SHARE Email Facebook Twitter April 12, 2016 Budget News, Fiscal Cliff, Press Release Harrisburg, PA – A new Moody’s report has affirmed Pennsylvania’s negative rating. The report cites Pennsylvania’s “negative fiscal position following years of deficits and large structural imbalance” and “poorly funded pension plans and historical practice of underfunding” as chief credit challenges. Furthermore, our “failure to address [the] structural budget gap” could lead to credit downgrade.“As I have warned for years, we must address Pennsylvania’s structural budget deficit,” said Governor Wolf. “Either we can invest in education, eliminate the deficit, and put Pennsylvania back on track or we can continue on the same path with dire consequences. If we do not act, a more than $2 billion deficit will force cuts to education funding and human services while increasing property taxes for people across Pennsylvania.”Last month, Moody’s, PNC, and S&P gave similar warnings:S&P: “The outlook is negative. The negative outlook reflects our view that although the passage of the fiscal 2016 budget lays the groundwork for deliberations on the fiscal 2017 budget, lawmakers still face a projected budget gap for fiscal 2017. By failing to address long-term structural balance in fiscal 2016, lawmakers have pushed difficult fiscal decisions to the fiscal 2017 budget…Our negative outlook rather reflects our view that the state’s fiscal issues lie in lack of political will to solve them in a timely manner…”Moody’s: “Pennsylvania’s 2016 Budget Doesn’t Solve Its Long-Term Challenges: On Wednesday, March 23, Commonwealth of Pennsylvania (Aa3 negative) Governor Tom Wolf said he would not veto the fiscal 2016 budget the legislature had passed, smoothing the way for the budget bill to become law on March 28. This officially ends the stalemate over Pennsylvania’s fiscal 2016 budget, but only brings to the fore a likely new stalemate over the budget for the fiscal year that starts July 1 and ongoing questions over the state’s progress toward structural balance over the longer term.”PNC: .”We do not expect the budget to come close to solving Pennsylvania’s fiscal pressures, including its structural budget gap, which is sizeable and growing. Without broader policy changes, Pennsylvania’s structural deficit will worsen.”# # #Like Governor Tom Wolf on Facebook: Facebook.com/GovernorWolf
This two-bedroom unit at 3/31 Capparis St, Algester, is on the market for offers over $240,000.PRDnationwide calculated the five hot spots using a new methodology that factored in affordability, but also considered location (within a 20km radius from the CBD), price growth, rental yields, project development, and liveability factors such as a low crime rate, access to amenities and a lower than average unemployment rate. CRICKETER’S HOME READY FOR AUCTION PRDnationwide national research manager Diaswati Mardiasmo said it was a surprise to see Algester come out on top for both property types.“It’s not the first suburb that might come to mind for people when it comes to a hot spot,” Dr Mardiasmo said.“But that’s the good thing about this report — it does unearth suburbs people don’t ordinarily think about.” Inside the house at 37 Blarney St, Bracken Ridge.When it comes to units, Northgate, less than 10km from the CBD, is the next hotspot after Algester.The suburb has recorded annual price growth of 7.5 per cent since 2016, yet is still affordable with a median unit price of $414,000. This four-bedroom house at 33 Owenia St, Algester, is for sale.“When we moved here, it was still up and coming, but there’s been lots of development since,” Mrs Dunwell said.“That’s benefited us because there are a lot more parks and green space, so it’s really opened it up to more families.“It’s close to the city, but you don’t have the hustle and bustle.”More from newsParks and wildlife the new lust-haves post coronavirus17 hours agoNoosa’s best beachfront penthouse is about to hit the market17 hours agoSelling agent Lynda Simpson of LJ Hooker Algester lived there for 27 years and now lives next door in Parkinson.“I love the suburb,” she said. BRISBANE ONE BEDDER SELLS FOR $2.6M Inside the unit at 3/169 Flower St, Northgate.On the city’s south side, Algester’s neighbour, Parkinson, is described as a “hidden gem”.Since 2016, the suburb has recorded unit price growth of 8.7 per cent and investors are benefiting from rental yields of 5.4 per cent.This year, $12 million worth of residential development is expected to add 42 new townhouses to the area, which will provide opportunities for first home buyers.Place Advisory director Lachlan Walker said there were three key things to consider when choosing the next hot spot — population growth, infrastructure investment and employment opportunities.“Generally, areas which tick two of these three boxes see the third element derived through demand,” Mr Walker said.His hot spots to watch are Stafford in Brisbane’s north, Balmoral in the east, Indooroopilly and Rocklea in the west, and the inner-city suburb of Red Hill. A two-bedroom unit in this complex at 169 Flower St, Northgate, is for sale for $329,990. This three-bedroom house at 37 Blarney St, Bracken Ridge, is on the market for $450,000.A number of housing infrastructure and commercial projects are set to boost economic growth in the area, while a low rental vacancy rate and solid rental yield make Bracken Ridge “an investment hotbed”. Paul and Stacey Dunwell with kids Jaxen, 13, Rory, 9, and Kobi, 14, at their home in Algester. Image: AAP/John Gass.Ms Simpson said Algester was popular among owner-occupiers and renovators upgrading three-bedroom houses into four-bedroom, two-bathroom homes.She said the suburb appealed to families because it had good schools and was still affordable.“There are lots of active buyers. As long as they’re in the right price range, homes sell quick.”On Brisbane’s northside, Bracken Ridge, about 15km from the CBD, was identified as a hotspot for houses because of its low entry price point, liveability and median price growth of more than four per cent in the past 15 months. Paul and Stacey Dunwell with kids Jaxen, 13, Rory, 9, and Kobi, 14, at their home in Algester. Image: AAP/John Gass.THE often forgotten pocket of Algester has been singled out as the most affordable and liveable suburb in Brisbane.First home buyers and investors are being urged to act fast to secure a home in the suburb, 16km south of the CBD, with the median price of units jumping more than 17 per cent since 2016 and house prices rising five per cent.Algester takes out first place in the latest PRDnationwide Brisbane hot spot report, with the suburb classed as affordable and liveable for both houses and units. Only five suburbs made the cut. GET THE LATEST REAL ESTATE NEWS DIRECT TO YOUR INBOX HERE Bracken Ridge and Geebung are the next best hot spots to buy or invest in houses, while Northgate and Parkinson are the next best for units.According to the property research firm, Algester offers the best of both worlds given its lower entry prices and proximity to supermarkets, parkland, public schools, a medical centre and the motorway. PRDnationwide national research manager Diaswati Mardiasmo.Dr Mardiasmo said this was the first year PRDnationwide had considered liveability as well as affordability in its capital city hot spot report.“When you look at affordability, the suburbs then shift away from the Ascots, Hamiltons and Bulimbas and Hawthornes to suburbs in the north and south,” she said.“And then you put the liveability aspect on top of that … you’re getting good quality suburbs.”Dr Mardiasmo said adding the liveability factor weeded out the suburbs that might be affordable, but didn’t meet the criteria to make them a good place to invest or live in. WORST OVER FOR BRISBANE LANDLORDS The report found the three lowest priced suburbs within 20km of the CBD were Ellen Grove, Inala and Acacia Ridge, while the three highest priced suburbs were Teneriffe, Ascot and New Farm — but none of these were considered liveable or affordable enough to be a hot spot.Stacey and Paul Dunwell have lived in Algester for the past 14 years, bringing up their three sons in the suburb.They are reluctantly selling their house at 33 Owenia St, Algester due to sporting opportunities overseas that have arisen for one of their boys. This four-bedroom house at 33 Owenia St, Algester, is for sale for $565,000.Investors have enjoyed solid rental yields for units of 5.4 per cent and 4.1 per cent for houses — above the Brisbane average.In the first half of 2018, around $1.5 million worth of residential development occurred in Algester, which will add 35 new housing lots to the area. This two-bedroom house at 118 Webster Rd, Stafford, is available for offers over $419,000.BRISBANE’S MOST AFFORDABLE & LIVEABLE HOTSPOTSSuburb Property type Median house price Median unit priceAlgester Houses and units $514,500 $365,000 Bracken Ridge Houses $500,000 $325,000Geebung Houses $538,000 $362,500Northgate Units $645,000 $414,000Parkinson Units $663,500 $401,000 (Source: PRDnationwide and CoreLogic)
Tulip Oil Netherlands Offshore B.V. has awarded Heerema Fabrication Group (HFG) an engineering, procurement, construction and installation (EPCI) contract for the Q10-A unmanned offshore platform to be installed in the North Sea.Tulip Oil Netherlands Offshore B.V. (Tulip Oil) is a subsidiary of Tulip Oil Holding B.V., a privately-held exploration and production operator based in The Hague. Tulip Oil is the license holder (60% interest) and operator of the Q7 and Q10a licenses along with its partner EBN (40%).Tulip Oil recently made the Final Investment Decision (FID) for the development of the Q10 gas field, located 20 km offshore the Netherlands in a shallow water environment. The field development will encompass an unmanned offshore platform (Q10-A) with a pipeline tie back to the TAQA-operated P15d platform to the south east of the platform. First gas is expected in 2019.At the time, the company also revealed that the pipeline scope for the project had been awarded to Allseas and the production platform scope to Heerema.Heerema confirmed the EPCI contract award in a statement on Tuesday. The company also added that the topside of the Q10-A platform will have a weight of approximately 500 tonnes. The jacket will have a weight of around 600 tonnes and will stand in 21 meters of water. The Q10-A platform will be installed in late 2018.Koos-Jan van Brouwershaven, CEO of Heerema Fabrication Group, stated: “This project is a good example of HFG’s competence to develop a project from the client’s functional requirements through to the final delivery offshore. We will perform the full platform FEED and EPCI in one continuous program, rather than the traditional multi-stage approach. This enables a fast-track delivery program, resulting in lower execution risk.”
The Historical Association Sliedrecht (Historische Vereniging Sliedrecht) will host a lecture named ‘The Wonderful World of Hydraulic Engineering – Dredging’ on Thursday, March 21, 2019 in Sliedrecht, the Netherlands.Dredging is much more than bringing sand to the surface, it is the whole world of hydraulic engineering, said the Association in its announcement.The construction of new ports, land reclamation in Hong Kong, the Palm Islands Project in Dubai, construction of Maasvlakte 1 and Maasvlakte 2, extension of the Suez Canal etc. are just some of the projects that dredgers have conducted all over the world.During the lecture, the past, present and future of dredging – together with some amazing dredging photos – will be introduced.A fascinating story about man and his machines, presented by two old dredgers, volunteers from the National Dredging Museum, will also be part of the event.The lecture will take place in the Grienden College large room, starting at 7:30 PM.
On a wet and rainy night, the Batesville JV football team beat Jennings County 26-6 in their first game of the season. Scoring touchdowns for the Bulldogs were Josh Mobley on a 8 yard run, Will Meer on a 2 yard run, Bryson Bonelli on a 5 yard run, and Brady Hornberger on a 26 yard pass from Bonelli. Jacob Meer scored the only 2 point conversion on a pass from Bonelli.The defense was led by Nick McConnell, Nate Deputy, and Vonley Hund. Will Meer and Luke Wilson added interceptions for a Bulldog defense that didn’t allow a score as Jennings County’s TD came on a turnover.Courtesy of Bulldogs Coach Tony Gausman.
Carver confronted some of Newcastle’s travelling supporters before the 4-0 defeat to Southampton on Saturday after seeing a ‘Pardew Out’ banner unfurled in the stand at St Mary’s. Magpies boss Alan Pardew is under increasing pressure at St James’ Park with his team sitting bottom of the Barclays Premier League after claiming just two points in their opening four games. Newcastle assistant boss John Carver and goalkeeping coach Andy Woodman have both issued apologies after clashes with fans at the weekend. Woodman, meanwhile, got himself in hot water after posting an inappropriate private message to a supporter on Twitter which was then made public. “I am very sorry for the ill-advised comment I posted privately on Twitter on Sunday morning, which was subsequently made public,” he said. “It was never my intention, of course, for my response to enter the public domain. My response was a reaction to significant personal abuse I received from a number of fans which I felt exceeded that which was fair and balanced. “That said I understand my response was unacceptable and I regret my actions and apologise for any offence caused.” The furore will come as a blow to Pardew whose relationship with the Newcastle faithful was already at a low ebb before the weekend’s events. The Magpies face Hull at St James’ Park on Saturday with Tigers boss Steve Bruce among those touted to replace Pardew should owner Mike Ashley decide a change of direction is needed in the dugout. Press Association The club confirmed they received complaints from supporters following Carver’s altercation and have now dealt with the matter internally. “My sole focus on Saturday, as it always is, was on trying to gain three points for Newcastle United and preparing the players to the best of my ability,” Carver said in a club statement. “This included keeping them focused on their roles and duties in the upcoming 90 minutes. “In the warm up, I was disappointed to see banners that could, in my opinion, distract the players and take focus away from the job in hand – namely winning the match. “I went over to our fans to ask them to help us and requested that they take the banners down. The vast majority of supporters back the team through thick and thin and I am very proud to be one of them. “I was met with abuse from one supporter and I regret that I responded inappropriately. I sincerely apologise for any offence caused by my reaction. “Every fan is entitled to an opinion, positive or negative, and I respect that. I hope fans will understand that I, like them, only wanted what was best for the team. “I am proud to work for my home town club and would ask every supporter to back the players and all staff, as they really can make a difference.”
James Morrison’s header proved the difference in the Baggies’ first Premier League victory under Alan Irvine against a Spurs side looking toothless, sloppy and ponderous throughout. “The beginning of the game was wrong,” a clearly agitated Pochettino said. “We were very slow, we moved the ball very slow, there was a slow tempo. In football, you need to play quick. “The way that we played, I think was wrong because we played very, very slow from the beginning. “I am angry or disappointed – I don’t know the best word to show my feelings. “We had a bad day. I am very disappointed because we had a very bad day, we played very slowly. “During the game, the team looked very nervous. I think the result is not fair because I think a draw is, if you analyse the game.” Pochettino refused to blame Thursday’s Europa League trip to Partizan Belgrade for the disappointing performance in a match he admitted he needed to “fix” their toothlessness in front of goal. Tottenham head coach Mauricio Pochettino was angered by his side’s lack of passion in a poor display which saw West Brom end their winless start to the campaign. Spurs managed just one shot on target and looked flaky at the back, with the players not showing the same passion their manager did on the touchline. “This is my surprise,” Pochettino said when it was suggested his players were subdued. “I think we need to show more. “We need to show more because each and every game in the Premier League is difficult. “Maybe West Brom arrived to White Hart Lane with only two points and last in the table, but we need to show respect. “I believe that we were wrong in our way and we played very slow, there was a lack of movement. You need play football that is aggressive. “We were wrong, we were wrong in this way. Always it is difficult when the opponent believes in themselves and you need to show that you are the best team in the way we play, always you put risk in your game.” There were no such problems for West Brom, who fully deserved their win after a performance that belied their lowly position. Joleon Lescott would have capped a fine debut with a first-half goal was it not for an unfortunate block by team-mate Craig Dawson, who should have won a penalty after his header was handled by Emmanuel Adebayor. Hugo Lloris was also tested on a number of occasions but West Brom were not to be denied a first league win under Irvine. Eyebrows were raised when the Scot was named Pepe Mel’s successor in the summer, with the Baggies’ alarming start to the season exacerbating fans’ concerns. “Watching Match of the Day last night, the table didn’t look very nice,” Irvine said of the pressure. “When you’ve got a game in hand, it does not necessarily mean you’re going to get the points from that game, especially when you are coming to White Hart Lane. “I suppose I would be lying if I said there wasn’t an element of relief, but the over-riding emotion is one of real pleasure for the players, for the club as a whole, everybody involved and, of course, for our fans. I am more pleased than relieved.” Life at the Spurs helm could not have begun any better for the former Argentina international, but that four-match winning start has since been replaced by a run of four games without a victory in all competitions. The latest frustration came against West Brom, who started the day without a win at the bottom of the table yet left White Hart Lane deserved 1-0 victors. Press Association